A Case of Euglycemic Diabetic Ketoacidosis in a Patient With Type 2 Diabetes Mellitus and COVID-19.

covid 19 diabetes mellitus type 2 diabetic ketoacidosis (dka) emergency department euglycemic dka medical intensive care unit sars-cov-2

Journal

Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737

Informations de publication

Date de publication:
11 Dec 2020
Historique:
entrez: 18 1 2021
pubmed: 19 1 2021
medline: 19 1 2021
Statut: epublish

Résumé

Diabetic ketoacidosis (DKA) can cause significant morbidity and mortality in patients with type 1 or type 2 diabetes mellitus. DKA causes an approximate annual hospitalization rate of 6.3% and in-hospital case-fatality rate of 0.4%. A subset of DKA cases termed euglycemic diabetic ketoacidosis (eu-DKA) is characterized by euglycemia (<200 mg/dL), high anion gap metabolic acidosis, and an increased plasma ketone concentration. This clinical syndrome comprises approximately 2.6% to 3.2% of total DKA admissions, making it a rare condition. In this case report, a male patient was diagnosed with coronavirus disease 2019 (COVID-19) three days prior to arriving at the emergency department. Upon evaluation, he displayed severe acidemia and was diagnosed with eu-DKA. He was started on intravenous regular insulin and D5 one-half normal saline, which markedly improved his metabolic status. Notably, his admission was uncomplicated by respiratory symptoms of COVID-19. It is proposed that his eu-DKA was catalyzed by his recent COVID-19 infection. Recent studies that have shown COVID-19 may increase lipolysis and induce ketogenesis in susceptible patients.

Identifiants

pubmed: 33457131
doi: 10.7759/cureus.12029
pmc: PMC7797421
doi:

Types de publication

Case Reports

Langues

eng

Pagination

e12029

Informations de copyright

Copyright © 2020, Morrison et al.

Déclaration de conflit d'intérêts

The authors have declared that no competing interests exist.

Références

N Engl J Med. 2016 Mar 17;374(11):1094
pubmed: 26981940
Acta Clin Belg. 2020 Jun 16;:1-5
pubmed: 32544373
Endocr J. 2011;58(12):1045-53
pubmed: 22033476
Clin Infect Dis. 2020 Nov 5;71(8):1937-1942
pubmed: 32301997
Diabetes. 2002 Dec;51(12):3391-9
pubmed: 12453891
Diabetol Int. 2020 Oct 28;:1-4
pubmed: 33133998
Am J Nephrol. 1997;17(1):36-41
pubmed: 9057951
Ann Intern Med. 1986 Dec;105(6):836-40
pubmed: 3096181
MMWR Morb Mortal Wkly Rep. 2018 Mar 30;67(12):362-365
pubmed: 29596400
Diabetes Care. 2015 Sep;38(9):1638-42
pubmed: 26294774
Diabetes Obes Metab. 2020 Oct;22(10):1935-1941
pubmed: 32314455
Diabetes Care. 2018 Sep;41(9):1839-1841
pubmed: 30135197
J Clin Endocrinol Metab. 2020 Aug 1;105(8):
pubmed: 32556147

Auteurs

Nathan Morrison (N)

Internal Medicine, Philadelphia College of Osteopathic Medicine, Philadelphia, USA.

Katherine Barnett (K)

Internal Medicine, Philadelphia College of Osteopathic Medicine, Philadelphia, USA.

Julianna Tantum (J)

Internal Medicine, Lankenau Medical Center, Wynnewood, USA.

Hannah K Morrison (HK)

Emergency Medicine, Lankenau Medical Center, Wynnewood, USA.

Michael Whalen (M)

Emergency Medicine, Lankenau Medical Center, Wynnewood, USA.

Classifications MeSH