LSD1 is an environmental stress-sensitive negative modulator of the glutamatergic synapse.
Aging
Alternative splicing
Environmental stress
Epigenetics
Glutamatergic synapse
LSD1/KDM1A
Neuroplasticity
Psychiatric disorders
REST/NRSF
Journal
Neurobiology of stress
ISSN: 2352-2895
Titre abrégé: Neurobiol Stress
Pays: United States
ID NLM: 101643409
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
15
08
2020
revised:
19
11
2020
accepted:
22
11
2020
entrez:
18
1
2021
pubmed:
19
1
2021
medline:
19
1
2021
Statut:
epublish
Résumé
Along with neuronal mechanisms devoted to memory consolidation -including long term potentiation of synaptic strength as prominent electrophysiological correlate, and inherent dendritic spines stabilization as structural counterpart- negative control of memory formation and synaptic plasticity has been described at the molecular and behavioral level. Within this work, we report a role for the epigenetic corepressor Lysine Specific Demethylase 1 (LSD1) as a negative neuroplastic factor whose stress-enhanced activity may participate in coping with adverse experiences. Constitutively increasing LSD1 activity via knocking out its dominant negative splicing isoform neuroLSD1 (neuroLSD1
Identifiants
pubmed: 33457471
doi: 10.1016/j.ynstr.2020.100280
pii: S2352-2895(20)30070-9
pmc: PMC7794663
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100280Informations de copyright
© 2020 The Authors.
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