Dopamine induces functional extracellular traps in microglia.

Cell Biology Cellular Neuroscience Immunology Molecular Biology

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
22 Jan 2021
Historique:
received: 11 09 2020
revised: 26 11 2020
accepted: 16 12 2020
entrez: 18 1 2021
pubmed: 19 1 2021
medline: 19 1 2021
Statut: epublish

Résumé

Dopamine (DA) plays many roles in the brain, especially in movement, motivation, and reinforcement of behavior; however, its role in regulating innate immunity is not clear. Here, we show that DA can induce DNA-based extracellular traps in primary, adult, human microglia and BV2 microglia cell line. These DNA-based extracellular traps are formed independent of reactive oxygen species, actin polymerization, and cell death. These traps are functional and capture fluorescein (FITC)-tagged

Identifiants

pubmed: 33458617
doi: 10.1016/j.isci.2020.101968
pii: S2589-0042(20)31165-2
pmc: PMC7797945
doi:

Types de publication

Journal Article

Langues

eng

Pagination

101968

Informations de copyright

© 2020 The Author(s).

Déclaration de conflit d'intérêts

The authors declare no competing interests.

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Auteurs

Ishan Agrawal (I)

Department of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur, Jodhpur, Rajasthan 342037, India.

Nidhi Sharma (N)

Department of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur, Jodhpur, Rajasthan 342037, India.
Karolinska Institute and Scilifelab, Stockholm, Sweden.

Shivanjali Saxena (S)

Department of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur, Jodhpur, Rajasthan 342037, India.

S Arvind (S)

Department of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur, Jodhpur, Rajasthan 342037, India.

Debayani Chakraborty (D)

Department of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur, Jodhpur, Rajasthan 342037, India.

Debarati Bhunia Chakraborty (DB)

Department of Computer Science and Engineering, Indian Institute of Technology Jodhpur, Jodhpur, Rajasthan 342037, India.

Deepak Jha (D)

Department of Neurosurgery, All India Institute of Medical Sciences Jodhpur, Jodhpur, 342005 Rajasthan, India.

Surajit Ghatak (S)

Department of Anatomy, All India Institute of Medical Sciences Jodhpur, Jodhpur, 342005 Rajasthan, India.

Sridhar Epari (S)

Department of Pathology, Tata Memorial Hospital, Mumbai, 400012 Maharashtra, India.

Tejpal Gupta (T)

Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, 400012, Maharashtra, India.

Sushmita Jha (S)

Department of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur, Jodhpur, Rajasthan 342037, India.

Classifications MeSH