Sentinel lymph node biopsy predicts systemic recurrence in digital papillary adenocarcinoma.
digital papillary adenocarcinoma
sentinel lymph node biopsy
sweat gland carcinoma
Journal
Journal of surgical oncology
ISSN: 1096-9098
Titre abrégé: J Surg Oncol
Pays: United States
ID NLM: 0222643
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
26
07
2020
accepted:
02
08
2020
entrez:
18
1
2021
pubmed:
19
1
2021
medline:
26
1
2021
Statut:
ppublish
Résumé
Digital papillary adenocarcinoma (DPA) is a rare, aggressive neoplasm of sweat gland origin. It can recur at local, regional, or distant sites. There is limited knowledge about the role of sentinel lymph node biopsy (SLNB) in predicting recurrence in these patients. We present our experience with this uncommon tumor to evaluate the role of SLNB in predicting outcome. Medical records of all patients who underwent surgical treatment for biopsy-proven upper extremity DPA at the study institution were reviewed. Descriptive statistics and Fisher's exact test were used to analyze data. Twenty-one patients were identified. Most patients were male (71%), and the median age was 51 years. SLNB was performed in 18 patients; three were positive for nodal metastatic disease (17%). At a median follow-up of 53 months, there were no local recurrences and two cases of systemic recurrence. No patient with a negative sentinel lymph node has evidence of metastasis or recurrence. Fisher's exact test demonstrated a significant association between a positive SLNB and recurrence (P = .02). SLNB revealed metastatic disease in 17% of patients with DPA and appears to predict systemic recurrence in this small series.
Sections du résumé
BACKGROUND AND OBJECTIVES
OBJECTIVE
Digital papillary adenocarcinoma (DPA) is a rare, aggressive neoplasm of sweat gland origin. It can recur at local, regional, or distant sites. There is limited knowledge about the role of sentinel lymph node biopsy (SLNB) in predicting recurrence in these patients. We present our experience with this uncommon tumor to evaluate the role of SLNB in predicting outcome.
METHODS
METHODS
Medical records of all patients who underwent surgical treatment for biopsy-proven upper extremity DPA at the study institution were reviewed. Descriptive statistics and Fisher's exact test were used to analyze data.
RESULTS
RESULTS
Twenty-one patients were identified. Most patients were male (71%), and the median age was 51 years. SLNB was performed in 18 patients; three were positive for nodal metastatic disease (17%). At a median follow-up of 53 months, there were no local recurrences and two cases of systemic recurrence. No patient with a negative sentinel lymph node has evidence of metastasis or recurrence. Fisher's exact test demonstrated a significant association between a positive SLNB and recurrence (P = .02).
CONCLUSION
CONCLUSIONS
SLNB revealed metastatic disease in 17% of patients with DPA and appears to predict systemic recurrence in this small series.
Identifiants
pubmed: 33459374
doi: 10.1002/jso.26170
pmc: PMC8494386
mid: NIHMS1726619
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1323-1327Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Informations de copyright
© 2020 Wiley Periodicals LLC.
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