Stiffness Tomography of Ultra-Soft Nanogels by Atomic Force Microscopy.
atomic force microscopy
soft matter
stiffness tomography
surface analysis
temperature-sensitive nanogels
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
01 Feb 2021
01 Feb 2021
Historique:
received:
25
08
2020
pubmed:
19
1
2021
medline:
19
1
2021
entrez:
18
1
2021
Statut:
ppublish
Résumé
The softness of nanohydrogels results in unique properties and recently attracted tremendous interest due to the multi-functionalization of interfaces. Herein, we study extremely soft temperature-sensitive ultra-low cross-linked (ULC) nanogels adsorbed to the solid/water interface by atomic force microscopy (AFM). The ultra-soft nanogels seem to disappear in classical imaging modes since a sharp tip fully penetrates these porous networks with very low forces in the range of steric interactions (ca. 100 pN). However, the detailed evaluation of Force Volume mode measurements allows us to resolve their overall shape and at the same time their internal structure in all three dimensions. The nanogels exhibit an extraordinary disk-like and entirely homogeneous but extremely soft structure-even softer than polymer brushes. Moreover, the temperature-sensitive nanogels can be switched on demand between the ultra-soft and a very stiff state.
Identifiants
pubmed: 33459462
doi: 10.1002/anie.202011615
pmc: PMC7898630
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2280-2287Subventions
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : Sonderforschungsbereich SFB 985 "Functional Microgels and Microgel Systems"
Informations de copyright
© 2020 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.
Références
Nanoscale. 2018 Aug 30;10(34):16050-16061
pubmed: 30106410
Nat Commun. 2019 Jun 4;10(1):2436
pubmed: 31164639
Mater Horiz. 2018 Nov 1;5(6):1130-1136
pubmed: 30450211
Nat Mater. 2014 Oct;13(10):979-87
pubmed: 25108614
Biotechnol Bioeng. 2009 Jul 1;103(4):655-63
pubmed: 19472329
ACS Nano. 2011 Jan 25;5(1):315-20
pubmed: 21174404
Angew Chem Int Ed Engl. 2017 Jun 19;56(26):7380-7386
pubmed: 28524364
Macromol Rapid Commun. 2020 Jul;41(13):e2000135
pubmed: 32483937
Soft Matter. 2014 Sep 28;10(36):7045-50
pubmed: 24954112
Biophys J. 2009 Jul 22;97(2):674-7
pubmed: 19619482
Adv Healthc Mater. 2018 Mar;7(6):e1701067
pubmed: 29369541
Nat Mater. 2014 Dec;13(12):1108-1114
pubmed: 25194701
Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):885-890
pubmed: 28100492
Nat Protoc. 2011 Sep 01;6(9):1443-52
pubmed: 21886107
Nat Commun. 2018 Sep 4;9(1):3584
pubmed: 30181577
Angew Chem Int Ed Engl. 2017 Jan 2;56(1):225-229
pubmed: 27900823
Angew Chem Int Ed Engl. 2021 Feb 1;60(5):2280-2287
pubmed: 33459462
Nat Methods. 2012 Jul 30;9(8):774-5
pubmed: 22847110
Science. 2005 Nov 18;310(5751):1139-43
pubmed: 16293750
Angew Chem Int Ed Engl. 2019 Jun 24;58(26):8809-8813
pubmed: 31056848
Langmuir. 2018 Apr 10;34(14):4150-4158
pubmed: 29509428
ACS Nano. 2013 Nov 26;7(11):10387-96
pubmed: 24131492
Anal Chem. 2017 Jun 6;89(11):6091-6098
pubmed: 28467056
J Chem Phys. 2004 Apr 1;120(13):6197-206
pubmed: 15267506
Nat Methods. 2016 Apr 28;13(5):405-14
pubmed: 27123816
ACS Nano. 2019 Apr 23;13(4):4548-4559
pubmed: 30865829
J Mol Recognit. 2012 May;25(5):278-84
pubmed: 22528189
Soft Matter. 2015 Mar 14;11(10):2018-28
pubmed: 25648590
Langmuir. 2009 Sep 15;25(18):10624-32
pubmed: 19735134
Nano Lett. 2019 Nov 13;19(11):8161-8170
pubmed: 31613114
Adv Colloid Interface Sci. 2000 Feb 1;85(1):1-33
pubmed: 10696447
ACS Nano. 2016 Jan 26;10(1):1386-94
pubmed: 26687925
Nano Lett. 2016 Nov 9;16(11):7295-7301
pubmed: 27701865
ACS Appl Mater Interfaces. 2020 Jul 29;12(30):33516-33529
pubmed: 32631046
Sensors (Basel). 2014 May 21;14(5):8984-95
pubmed: 24854361
Adv Mater. 2019 Dec;31(49):e1903668
pubmed: 31621960
Angew Chem Int Ed Engl. 2020 Jan 13;59(3):1248-1255
pubmed: 31664769
Langmuir. 2019 Nov 19;35(46):14769-14781
pubmed: 31638406
Angew Chem Int Ed Engl. 2018 Sep 17;57(38):12280-12284
pubmed: 30070009
Langmuir. 2018 Jun 19;34(24):7067-7076
pubmed: 29772184
ACS Appl Mater Interfaces. 2014 Oct 22;6(20):17702-12
pubmed: 25272373
Nat Commun. 2019 Mar 29;10(1):1418
pubmed: 30926786
Nano Lett. 2017 Jun 14;17(6):3782-3791
pubmed: 28326790
ACS Appl Mater Interfaces. 2009 Dec;1(12):2747-54
pubmed: 20356152
Biomacromolecules. 2019 Jan 14;20(1):243-253
pubmed: 30512925
PLoS One. 2017 Jul 18;12(7):e0181369
pubmed: 28719648
Sci Adv. 2018 Apr 06;4(4):eaao7086
pubmed: 29740608