Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells.

Carrier Proteins / genetics Epithelial Cells / metabolism Germ-Line Mutation Humans Interferons / metabolism Kidney / metabolism Proto-Oncogene Proteins / genetics Tumor Suppressor Proteins / genetics

FLCN STAT2 TFE3 birt-hogg-dubé syndrome cancer biology genetics genomics human mTORC1 renal tumorigenesis

Journal

eLife

ISSN: 2050-084X

Titre abrégé: Elife

Pays: England

ID NLM: 101579614

Informations de publication

Date de publication:
18 01 2021

Historique:

received: 31 07 2020

accepted: 16 01 2021

pubmed: 19 1 2021

medline: 4 2 2022

entrez: 18 1 2021

Statut: epublish

Résumé

Germline mutations in the Folliculin (

Identifiants

DOI: 10.7554/eLife.61630 PMID: 33459596 PMC: PMC7899648

pubmed: 33459596

doi: 10.7554/eLife.61630

pii: 61630

pmc: PMC7899648

doi:

pii:

Substances chimiques

Carrier Proteins 0

FLCN protein, human 0

FNIP1 protein, human 0

FNIP2 protein, human 0

Proto-Oncogene Proteins 0

Tumor Suppressor Proteins 0

Interferons 9008-11-1

Banques de données

Dryad

['10.5061/dryad.6djh9w0zs']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Informations de copyright

Déclaration de conflit d'intérêts

IG, JK, JB, DW, TP, SP, SL, SD, PV, MR, Sv, FB, PP, Iv, JD, FZ, Rd, HM, AH, CJ, RW No competing interests declared

Références

J Cell Biol. 2019 Dec 2;218(12):4215-4235

pubmed: 31594807

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1624-31

pubmed: 25775561

Nat Methods. 2015 Apr;12(4):357-60

pubmed: 25751142

Elife. 2021 Jan 18;10:

pubmed: 33459596

PLoS One. 2019 Mar 7;14(3):e0212952

pubmed: 30845233

Nature. 1992 Jul 2;358(6381):83-6

pubmed: 1614538

Gene. 2008 May 31;415(1-2):60-7

pubmed: 18403135

Br J Cancer. 2011 Dec 6;105(12):1912-9

pubmed: 22146830

PLoS One. 2010 Dec 29;5(12):e15793

pubmed: 21209915

Bioinformatics. 2010 Feb 1;26(3):363-9

pubmed: 20007255

Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):106-16

pubmed: 25450743

Proteome Sci. 2013 Apr 23;11(1):17

pubmed: 23617947

Dev Cell. 2020 Mar 23;52(6):683-698.e7

pubmed: 32084359

Nat Commun. 2019 Feb 7;10(1):632

pubmed: 30733432

Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15552-7

pubmed: 17028174

Oncol Rep. 2005 May;13(5):949-56

pubmed: 15809763

Bioinformatics. 2014 Apr 1;30(7):923-30

pubmed: 24227677

Cancer Cell. 2002 Aug;2(2):157-64

pubmed: 12204536

Cell Host Microbe. 2016 Jun 8;19(6):882-90

pubmed: 27212660

Nat Med. 2018 Jul;24(7):939-946

pubmed: 29892062

Histopathology. 2018 Nov;73(5):758-766

pubmed: 29968390

Nat Commun. 2020 Mar 11;11(1):1310

pubmed: 32161258

Genes Dev. 2016 Nov 15;30(22):2551-2564

pubmed: 27913603

Nature. 2020 Sep;585(7826):597-602

pubmed: 32612235

PLoS Comput Biol. 2014 Jul 24;10(7):e1003731

pubmed: 25058159

Mol Cancer. 2010 Jun 23;9:160

pubmed: 20573232

Bioinformatics. 2011 Jun 15;27(12):1739-40

pubmed: 21546393

Arch Dermatol. 1977 Dec;113(12):1674-7

pubmed: 596896

CA Cancer J Clin. 2018 Jan;68(1):7-30

pubmed: 29313949

Pediatr Blood Cancer. 2019 Aug;66(8):e27766

pubmed: 31012542

J Natl Cancer Inst. 2005 Jun 15;97(12):931-5

pubmed: 15956655

Nat Methods. 2012 Mar 18;9(5):471-2

pubmed: 22426491

Pharmacol Ther. 2017 Nov;179:127-141

pubmed: 28546082

Cell Rep. 2020 Feb 11;30(6):1823-1834.e5

pubmed: 32049013

Physiol Rep. 2014 Aug 12;2(8):

pubmed: 25121506

Breast Cancer Res. 2008;10(4):R58

pubmed: 18627608

Science. 2017 Jun 16;356(6343):1188-1192

pubmed: 28619945

Eur Urol. 2006 May;49(5):798-805

pubmed: 16442207

Science. 1990 Aug 31;249(4972):1046-9

pubmed: 2144363

J Invest Dermatol. 2007 Mar;127(3):588-93

pubmed: 17124507

J Med Genet. 2010 Mar;47(3):182-9

pubmed: 19843504

Hum Mol Genet. 2011 Oct 1;20(19):3852-66

pubmed: 21752829

PLoS One. 2013 Jul 11;8(7):e66775

pubmed: 23874397

Cell. 1992 Aug 21;70(4):523-6

pubmed: 1505019

Proteomics Clin Appl. 2010 Jul;4(6-7):613-7

pubmed: 21137079

Kidney Int. 2015 Nov;88(5):1057-69

pubmed: 26083655

Cell. 2013 Apr 11;153(2):335-47

pubmed: 23582324

Cancer Epidemiol Biomarkers Prev. 2002 Apr;11(4):393-400

pubmed: 11927500

J Proteome Res. 2010 Apr 5;9(4):1913-22

pubmed: 20085282

Hum Pathol. 2019 Sep;91:52-60

pubmed: 31175917

Autophagy. 2014 Oct 1;10(10):1749-60

pubmed: 25126726

Cell Mol Life Sci. 2014 Jul;71(13):2483-97

pubmed: 24477476

PLoS One. 2013 Jul 29;8(7):e70030

pubmed: 23922894

Hum Mol Genet. 2013 Nov 1;22(21):4383-97

pubmed: 23784378

Sci Signal. 2020 Sep 15;13(649):

pubmed: 32934076

Genome Res. 2003 Nov;13(11):2498-504

pubmed: 14597658

Open Biol. 2012 Aug;2(8):120071

pubmed: 22977732

Inflamm Bowel Dis. 2012 Jun;18(6):1072-80

pubmed: 21994190

J Urol. 2005 May;173(5):1482-6

pubmed: 15821464

Oncogene. 2011 Mar 10;30(10):1159-73

pubmed: 21057536

Cell Rep. 2019 Mar 26;26(13):3613-3628.e6

pubmed: 30917316

Genes Dev. 2016 May 1;30(9):1034-46

pubmed: 27151976

ALTEX. 2017 Dec 2;35(2):223-234

pubmed: 29197217

Lab Invest. 1983 Sep;49(3):317-26

pubmed: 6193332

Int J Cancer. 2019 Apr 15;144(8):1941-1953

pubmed: 30350310

Cancer Genet Cytogenet. 2008 Jan 15;180(2):100-9

pubmed: 18206534

Bioinformatics. 2010 Jan 1;26(1):139-40

pubmed: 19910308

Front Immunol. 2017 Jan 26;8:29

pubmed: 28184222

J Med Genet. 2008 Jun;45(6):321-31

pubmed: 18234728

J Natl Cancer Inst. 2012 Nov 21;104(22):1750-64

pubmed: 23150719

Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50

pubmed: 16199517

Steroids. 2018 May;133:102-107

pubmed: 29097143

PLoS One. 2008;3(10):e3581

pubmed: 18974783

Bioinformatics. 2005 Aug 15;21(16):3448-9

pubmed: 15972284

Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613

pubmed: 30476243

Am J Hum Genet. 2005 Jun;76(6):1023-33

pubmed: 15852235

Mol Cell. 2013 Nov 21;52(4):495-505

pubmed: 24095279

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18722-7

pubmed: 19850877

Nat Med. 2018 Jul;24(7):927-930

pubmed: 29892067

Anal Chem. 2004 Jul 15;76(14):4193-201

pubmed: 15253663

Genes Dev. 2015 Oct 1;29(19):2010-21

pubmed: 26404941

Oncogene. 2008 Sep 11;27(40):5339-47

pubmed: 18663353

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2357-E2364

pubmed: 28270604

J Am Soc Nephrol. 2003 Oct;14(10):2581-7

pubmed: 14514735

Oncogene. 2009 Apr 2;28(13):1594-604

pubmed: 19234517

PLoS Genet. 2014 Apr 24;10(4):e1004273

pubmed: 24763318

Open Biol. 2015 Dec;5(12):150174

pubmed: 26631379

Hum Mutat. 2011 Aug;32(8):921-9

pubmed: 21538689

Cancers (Basel). 2019 Aug 03;11(8):

pubmed: 31382581

Am J Physiol Renal Physiol. 2008 Nov;295(5):F1365-75

pubmed: 18715936

J Cell Biol. 2013 Sep 30;202(7):1107-22

pubmed: 24081491

Front Genet. 2012 Dec 13;3:283

pubmed: 23248642