Interleukin-6 Interacts with Sleep Apnea Severity when Predicting Incident Alzheimer's Disease Dementia.
Alzheimer’s disease
dementia
inflammation
interleukin-6
sleep apnea
sleep disorders
sleep-disordered breathing
Journal
Journal of Alzheimer's disease : JAD
ISSN: 1875-8908
Titre abrégé: J Alzheimers Dis
Pays: Netherlands
ID NLM: 9814863
Informations de publication
Date de publication:
2021
2021
Historique:
pubmed:
19
1
2021
medline:
16
9
2021
entrez:
18
1
2021
Statut:
ppublish
Résumé
Because of their roles as potential risk factors, we evaluated whether obstructive sleep apnea (OSA) severity interacts with interleukin-6 (IL-6) in predicting incident dementia of the Alzheimer's type (DAT). In 269 dementia-free participants, IL-6 and the apnea-hypopnea index (AHI) were measured at baseline and incident DAT was surveilled for up to 22.8 years. Cox models revealed a significant interaction: In the lowest IL-6 quartile only, a higher AHI was associated with an elevated risk of DAT. The association between OSA severity and incident DAT might be especially apparent in the absence of inflammation or absence of potential benefits from IL-6.
Identifiants
pubmed: 33459710
pii: JAD200545
doi: 10.3233/JAD-200545
pmc: PMC8803404
mid: NIHMS1771685
doi:
Substances chimiques
IL6 protein, human
0
Interleukin-6
0
Types de publication
Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1451-1457Subventions
Organisme : NIA NIH HHS
ID : R01 AG054076
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201500001C
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG062531
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG008122
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201500001I
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC25195
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92019D00031
Pays : United States
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