Quantitative assessment of cytochrome C oxidase patterns in muscle tissue by the use of near-infrared spectroscopy (NIRS) in healthy volunteers.
Cellular oxygenation
Cytochrome C oxidase
NIRO-300
NIRS
Journal
Journal of clinical monitoring and computing
ISSN: 1573-2614
Titre abrégé: J Clin Monit Comput
Pays: Netherlands
ID NLM: 9806357
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
04
07
2020
accepted:
02
01
2021
pubmed:
19
1
2021
medline:
7
5
2022
entrez:
18
1
2021
Statut:
ppublish
Résumé
Cytochrome C oxidase (CCO) acts as final electron acceptor in the respiratory chain, possibly providing information concerning cellular oxygenation. CCO is a chromophore with a broad absorption peak in the near-infrared spectrum in its reduced state (835 nm). However, this peak overlaps with deoxygenated haemoglobin (HHb; 755 nm) which is present in much higher concentrations. NIRO-300 measures CCO signals, but did not receive FDA approval for this use due to presumed lack of independency of the measured CCO changes. However, there is no proven evidence for this assumption. We hypothesized that the NIRO-300 provides a HHb independent measurement of CCO concentration changes. In this single-center crossover randomized controlled trial in healthy volunteers, subjects were randomized to receive arterial occlusion to the left arm and venous stasis on the right arm (n = 5) or vice versa (n = 5) during 5 min. After a resting period, the second part of the cross over study was performed. We placed the NIRO-300 optodes bilateral at the level of the brachioradial muscle in order to collect NIRS data continuously. Data was analysed using a generalized additive mixed model. HHb and CCO follow a significant different trend over time during the intervention period for both arterial occlusion (F = 20.645, edf = 3.419, p < 0.001) and venous stasis (F = 9.309, edf = 4.931, p < 0.001). Our data indicate that CCO concentration changes were not affected by HHb changes, thereby proving independency.Clinical trial registration: B670201732023 on June 28, 2017.
Identifiants
pubmed: 33459945
doi: 10.1007/s10877-021-00648-6
pii: 10.1007/s10877-021-00648-6
doi:
Substances chimiques
Electron Transport Complex IV
EC 1.9.3.1
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
271-278Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature.
Références
Moerman A, Wouters P. Near-infrared spectroscopy (NIRS) monitoring in contemporary anaesthesia and critical care. Acta Anesthesiol Belg. 2009;61:185–94.
Bale G, Elwell CE, Tachtsidis I. From Jöbsis to the present day: a review of clinical near-infrared spectroscopy measurements of cerebral cytochrome-c-oxidase. J Biomed Opt. 2016;21(9):091307. https://doi.org/10.1117/1.JBO.21.9.091307 .
doi: 10.1117/1.JBO.21.9.091307
pubmed: 27170072
Piccoli C, Scrima R, Boffoli D, Capitanio N. Control by cytochrome c oxidase of the cellular oxidative phosphorylation system depends on the mitochondrial energy state. Biochem J. 2006;396(3):573–83. https://doi.org/10.1042/BJ20060077 .
doi: 10.1042/BJ20060077
pubmed: 16533168
pmcid: 1482809
Lange F, Dunne L, Hale L, Tachtsidis I. MAESTROS: a multiwavelength time-domain NIRS system to monitor changes in oxygenation and oxidation state of cytochrome-C-oxidase. IEEE J Sel Top Quantum Electron. 2019;25(1):7100312. https://doi.org/10.1109/JSTQE.2018.2833205 .
doi: 10.1109/JSTQE.2018.2833205
pubmed: 30450021
Boushel R, Piantadosi CA. Near-infrared spectroscopy for monitoring muscle oxygenation. Acta Physiol Scand. 2000;168:615–22. https://doi.org/10.1046/j.1365-201x.2000.00713x .
doi: 10.1046/j.1365-201x.2000.00713x
pubmed: 10759598
Elwell CE. A practical users guide to near-infrared spectroscopy. Beijing: Hamamatsu Photonics KK; 1995.
Al-Rawi PG, Smielewski P, Kirkpatrick PJ. Evaluation of a near-infrared spectrometer (NIRO 300) for the detection of intracranial oxygenation changes in the adult head. Stroke. 2001;32(11):2492–500. https://doi.org/10.1161/HS1101.098356 .
doi: 10.1161/HS1101.098356
pubmed: 11692006
Ferrari M, Wei Q, Carraresi L, De Blasi RA, Zaccanti G. Time-resolved spectroscopy of the human forearm. J Photochem Photobiol. 1992;16(2):141–53. https://doi.org/10.1016/1011-1344(92)80005-G .
doi: 10.1016/1011-1344(92)80005-G
Hamamatsu Photonics K.K. NIRO-300 online version v1.20.03
Gagnon RE, Macnab AJ, Gagnon FA, LeBlanc JG. Brain, spine, and muscle cytochrome Cu-A redox patterns of change during hypothermic circulatory arrest in swine. Comp Biochem Physiol A. 2005;141(3):264–70. https://doi.org/10.1016/j.cbpb.2005.04.003 .
doi: 10.1016/j.cbpb.2005.04.003
R Core Team. R. A language and environment for statistical computing. Vienna: R Core Team; 2018.
van Rij J, Wieling M, Baayen R, van Rijn H (2020) itsadug: interpreting time series and autocorrelated data using GAMMs. R package version 2.4
Akaike H. Information theory and an extension of the maximum likelihood principle. In: Selected papers of Hirotugu Akaike. New York: Springer; 1998. https://doi.org/10.1007/978-1-4612-1694-0_15 .
doi: 10.1007/978-1-4612-1694-0_15
Thavasothy M, Broadhead M, Elwell C, Peters M, Smith M. A comparison of cerebral oxygenation as measured by the NIRO 300 and the INVOS 5100 Near-Infrared Spectrophotometers. Anaesthesia. 2002;57(10):999–1006. https://doi.org/10.1046/j.1365-2044.2002.02826.x .
doi: 10.1046/j.1365-2044.2002.02826.x
pubmed: 12358958
Lange F, Dunne L, Tachtsidis I. Evaluation of haemoglobin and cytochrome responses during forearm ischaemia using multi-wavelength time domain NIRS. Adv Exp Med Biol. 2017;977:67–72. https://doi.org/10.1007/978-3-319-55231-6_1 .
doi: 10.1007/978-3-319-55231-6_1
pubmed: 28685429
pmcid: 6126221
Jones S, Chiesa ST, Chaturvedi N, Hughes AD. Recent developments in near-infrared spectroscopy (NIRS) for the assessment of local skeletal muscle microvascular function and capacity to utilise oxygen. Artery Res. 2016. https://doi.org/10.1016/j.artres.2016.09.001 .
doi: 10.1016/j.artres.2016.09.001
pubmed: 27942271
pmcid: 5134760
Davis ML, Barstow TJ. Estimated contribution of haemoglobin and myoglobin to near infrared spectroscopy. Respir Physiol Neurobiol. 2013;186(2):180–7. https://doi.org/10.1016/j.resp.2013.01.012 .
doi: 10.1016/j.resp.2013.01.012
pubmed: 23357615
Mesquida J, Gruartmoner G, Espinal C. Skeletal muscle oxygen saturation (StO
doi: 10.1155/2013/502194
pubmed: 24027757
pmcid: 3763593
Ferrari M, Muthalib M, Quaresima V. The use of near-infrared spectroscopy in understanding skeletal muscle physiology: recent developments. Trans R Soc A. 2011;369:4577–90. https://doi.org/10.1098/rsta.2011.0230 .
doi: 10.1098/rsta.2011.0230
Jones S, Kinsella M, Torlasco C, Kaynezhad P, de Roever I, Moon JC, et al. Improvements in skeletal muscle can be detected using broadband NIRS in first-time marathon runners. Adv Exp Med Biol. 2020. https://doi.org/10.1007/978-3-030-34461-0_31 .
doi: 10.1007/978-3-030-34461-0_31
pubmed: 32638345
Leung TS, Wittekind A, Binzoni T, Beneke R, Cooper CE, Elwell CE. Muscle oxygen saturation measured using “cyclic NIR signals” during exercise. Adv Exp Med Biol. 2010;662:183–9. https://doi.org/10.1007/978-1-4419-1241-1_26 .
doi: 10.1007/978-1-4419-1241-1_26
pubmed: 20204790
Ekbal NJ, Dyson A, Black C, Singer M. Monitoring tissue perfusion, oxygenation, and metabolism in critically ill patients. Chest. 2013;143(6):1799–808. https://doi.org/10.1378/chest.12-1849 .
doi: 10.1378/chest.12-1849
pubmed: 23732592
Hamaoka T, McCully KK, Quaresima V, Yamamoto K, Chance B. Near-infrared spectroscopy/imaging for monitoring muscle oxygenation and oxidative metabolism in healthy and diseased humans. J Biomed Opt. 2007;12(6):062105. https://doi.org/10.1117/1.2805437 .
doi: 10.1117/1.2805437
pubmed: 18163808
Mik EG, Balestra GM, Harms FA. Monitoring mitochondrial PO
doi: 10.1097/MCC.0000000000000719
pubmed: 32348095
Bale G, Rajaram A, Kewin M, Morrison L, Bainbridge A, Diop M, et al. Broadband NIRS cerebral cytochrome-C-oxidase response to anoxia before and after hypoxic-ischaemic injury in piglets. Cham: Springer; 2018. https://doi.org/10.1007/978-3-319-91287-5_24 .
doi: 10.1007/978-3-319-91287-5_24
Highton D, Chitnis D, Brigadoi S, Phan P, Tachtsidis I, Cooper R, et al. A fibreless multiwavelength NIRS system for imaging localised changes in cerebral oxidised cytochrome C oxidase. Adv Exp Med Biol. 2018. https://doi.org/10.1007/978-3-319-91287-5_54 .
doi: 10.1007/978-3-319-91287-5_54
pubmed: 30178368
Rajaram A, Bale G, Kewin M, Morrison LB, Tachtsidis I, St. Lawrence K, et al. Simultaneous monitoring of cerebral perfusion and cytochrome c oxidase by combining broadband near-infrared spectroscopy and diffuse correlation spectroscopy. Biomed Opt Express. 2018;9(6):2588. https://doi.org/10.1364/boe.9.002588 .
doi: 10.1364/boe.9.002588
pubmed: 30258675
pmcid: 6154190
de Roever I, Bale G, Cooper RJ, Tachtsidis I. Functional NIRS measurement of cytochrome-c-oxidase demonstrates a more brain-specific marker of frontal lobe activation compared to the haemoglobins. Adv Exp Med Biol. 2017;977:141–7. https://doi.org/10.1007/978-3-319-55231-6_19 .
doi: 10.1007/978-3-319-55231-6_19
pubmed: 28685438
pmcid: 6126217
Arifler D, Zhu T, Madaan S, Tachtsidis I. Optimal wavelength combinations for near-infrared spectroscopic monitoring of changes in brain tissue hemoglobin and cytochrome c oxidase concentrations. Biomed Optic Express. 2015. https://doi.org/10.1364/BOE.6.000933 .
doi: 10.1364/BOE.6.000933