Transcriptomic, proteomic, and biochemical analyses reveal a novel neuritogenesis mechanism of Naja naja venom α-elapitoxin post binding to TrkA receptor of rat pheochromocytoma cells.
Alpha‐cobrotoxin
Indian Cobra venom
MAPK pathway
alpha‐elapitoxin
nerve growth factor
neuritogenesis
snake venom
Journal
Journal of neurochemistry
ISSN: 1471-4159
Titre abrégé: J Neurochem
Pays: England
ID NLM: 2985190R
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
03
04
2020
revised:
28
07
2020
accepted:
30
07
2020
entrez:
18
1
2021
pubmed:
19
1
2021
medline:
3
3
2021
Statut:
ppublish
Résumé
This is the first report showing unique neuritogenesis potency of Indian Cobra N. naja venom long-chain α-neurotoxin (Nn-α-elapitoxin-1) exhibiting no sequence similarity to conventional nerve growth factor, by high-affinity binding to its tyrosine kinase A (TrkA) receptor of rat pheochromocytoma (PC-12) cells without requiring low-affinity receptor p
Substances chimiques
Elapid Venoms
0
Receptor, trkA
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
612-637Informations de copyright
© 2020 International Society for Neurochemistry.
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