A novel bio-active adhesive monomer induces odontoblast differentiation: a comparative study.
CMET
adhesive monomer
biocompatibility
dentine regeneration
odontoblast
Journal
International endodontic journal
ISSN: 1365-2591
Titre abrégé: Int Endod J
Pays: England
ID NLM: 8004996
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
25
03
2020
accepted:
06
07
2020
entrez:
18
1
2021
pubmed:
19
1
2021
medline:
21
1
2021
Statut:
ppublish
Résumé
To evaluate the in vitro effect of the novel adhesive monomer CMET, a calcium salt of 4-methacryloxyethyl trimellitate (4-MET), on the proliferation, mineralization and differentiation of odontoblast-like cells, comparing with 4-MET, calcium hydroxide (CH) and mineral trioxide aggregate (MTA). Rat odontoblast-like MDPC-23 cells were cultured in Dulbecco's modified Eagle's medium (DMEM) supplemented with 5% foetal bovine serum. The powder of four tested materials (CMET, 4-MET, CH and MTA) was first dissolved in distilled water (dH Cell viability was significantly greater in the CMET- (83 to 828 mmol L The novel bio-active monomer had the lowest cytotoxicity among all groups and it induced the proliferation, mineralization and differentiation of odontoblast-like cells under appropriate concentrations. This adhesive monomer possesses excellent biocompatibility and hence exhibits great potential in dentine regeneration.
Substances chimiques
Aluminum Compounds
0
Calcium Compounds
0
Dental Cements
0
Drug Combinations
0
Oxides
0
Silicates
0
Alkaline Phosphatase
EC 3.1.3.1
Calcium Hydroxide
PF5DZW74VN
Types de publication
Journal Article
Langues
eng
Pagination
1413-1429Subventions
Organisme : Japan Society for the Promotion of Science
ID : JP18H02979
Organisme : Japan Society for the Promotion of Science
ID : JP19K24127
Informations de copyright
© 2020 International Endodontic Journal. Published by John Wiley & Sons Ltd.
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