Past, present and future role of retinal imaging in neurodegenerative disease.
Alzheimer's disease
Cerebral small vessel disease
Huntington's disease
Imaging
Parkinson's disease
Retina
Journal
Progress in retinal and eye research
ISSN: 1873-1635
Titre abrégé: Prog Retin Eye Res
Pays: England
ID NLM: 9431859
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
21
08
2020
revised:
11
12
2020
accepted:
17
12
2020
pubmed:
19
1
2021
medline:
15
12
2021
entrez:
18
1
2021
Statut:
ppublish
Résumé
Retinal imaging technology is rapidly advancing and can provide ever-increasing amounts of information about the structure, function and molecular composition of retinal tissue in humans in vivo. Most importantly, this information can be obtained rapidly, non-invasively and in many cases using Food and Drug Administration-approved devices that are commercially available. Technologies such as optical coherence tomography have dramatically changed our understanding of retinal disease and in many cases have significantly improved their clinical management. Since the retina is an extension of the brain and shares a common embryological origin with the central nervous system, there has also been intense interest in leveraging the expanding armamentarium of retinal imaging technology to understand, diagnose and monitor neurological diseases. This is particularly appealing because of the high spatial resolution, relatively low-cost and wide availability of retinal imaging modalities such as fundus photography or OCT compared to brain imaging modalities such as magnetic resonance imaging or positron emission tomography. The purpose of this article is to review and synthesize current research about retinal imaging in neurodegenerative disease by providing examples from the literature and elaborating on limitations, challenges and future directions. We begin by providing a general background of the most relevant retinal imaging modalities to ensure that the reader has a foundation on which to understand the clinical studies that are subsequently discussed. We then review the application and results of retinal imaging methodologies to several prevalent neurodegenerative diseases where extensive work has been done including sporadic late onset Alzheimer's Disease, Parkinson's Disease and Huntington's Disease. We also discuss Autosomal Dominant Alzheimer's Disease and cerebrovascular small vessel disease, where the application of retinal imaging holds promise but data is currently scarce. Although cerebrovascular disease is not generally considered a neurodegenerative process, it is both a confounder and contributor to neurodegenerative disease processes that requires more attention. Finally, we discuss ongoing efforts to overcome the limitations in the field and unmet clinical and scientific needs.
Identifiants
pubmed: 33460813
pii: S1350-9462(20)30110-5
doi: 10.1016/j.preteyeres.2020.100938
pmc: PMC8280255
mid: NIHMS1666825
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100938Subventions
Organisme : NIA NIH HHS
ID : U01 AG051218
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005142
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG066524
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066546
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG062007
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG012435
Pays : United States
Organisme : NINDS NIH HHS
ID : UF1 NS100614
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066530
Pays : United States
Organisme : NINDS NIH HHS
ID : UH3 NS100614
Pays : United States
Organisme : NEI NIH HHS
ID : K08 EY027006
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
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