Multimethod investigation of the neurobiological basis of ADHD symptomatology in children aged 9-10: baseline data from the ABCD study.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
18 01 2021
18 01 2021
Historique:
received:
21
08
2020
accepted:
04
12
2020
revised:
30
11
2020
entrez:
19
1
2021
pubmed:
20
1
2021
medline:
22
6
2021
Statut:
epublish
Résumé
Attention deficit/hyperactivity disorder is associated with numerous neurocognitive deficits, including poor working memory and difficulty inhibiting undesirable behaviors that cause academic and behavioral problems in children. Prior work has attempted to determine how these differences are instantiated in the structure and function of the brain, but much of that work has been done in small samples, focused on older adolescents or adults, and used statistical approaches that were not robust to model overfitting. The current study used cross-validated elastic net regression to predict a continuous measure of ADHD symptomatology using brain morphometry and activation during tasks of working memory, inhibitory control, and reward processing, with separate models for each MRI measure. The best model using activation during the working memory task to predict ADHD symptomatology had an out-of-sample R
Identifiants
pubmed: 33462190
doi: 10.1038/s41398-020-01192-8
pii: 10.1038/s41398-020-01192-8
pmc: PMC7813832
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
64Subventions
Organisme : NIDA NIH HHS
ID : U24 DA041147
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041120
Pays : United States
Organisme : NIMH NIH HHS
ID : K08 MH121654
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041093
Pays : United States
Organisme : NIDA NIH HHS
ID : U24 DA041123
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041156
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041025
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041089
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041106
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041117
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041148
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA043593
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041174
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041134
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041022
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041028
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041048
Pays : United States
Commentaires et corrections
Type : ErratumIn
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