State-dependent responses to intracranial brain stimulation in a patient with depression.
Journal
Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
31
05
2020
accepted:
12
11
2020
pubmed:
20
1
2021
medline:
27
2
2021
entrez:
19
1
2021
Statut:
ppublish
Résumé
Deep brain stimulation is a promising treatment for severe depression, but lack of efficacy in randomized trials raises questions regarding anatomical targeting. We implanted multi-site intracranial electrodes in a severely depressed patient and systematically assessed the acute response to focal electrical neuromodulation. We found an elaborate repertoire of distinctive emotional responses that were rapid in onset, reproducible, and context and state dependent. Results provide proof of concept for personalized, circuit-specific medicine in psychiatry.
Identifiants
pubmed: 33462446
doi: 10.1038/s41591-020-01175-8
pii: 10.1038/s41591-020-01175-8
pmc: PMC8284979
mid: NIHMS1720919
doi:
Types de publication
Case Reports
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
229-231Subventions
Organisme : NIA NIH HHS
ID : R01 AG060477
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH111444
Pays : United States
Organisme : NINDS NIH HHS
ID : UH3 NS115631
Pays : United States
Organisme : NINDS NIH HHS
ID : UH3 NS109556
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG059794
Pays : United States
Organisme : NINDS NIH HHS
ID : K23 NS110962
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC015504
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
ID : K23NS110962
Organisme : NIDA NIH HHS
ID : U24 DA041123
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC012377
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS105675
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS098971
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG019724
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK117953
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH114860
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142051
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : ErratumIn
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