Lentiviral Expression of Rabies Virus Glycoprotein in the Rat Hippocampus Strengthens Synaptic Plasticity.
Dentate gyrus
Long-term potentiation
PDZ-binding motif
Plasticity
Rabies
Journal
Cellular and molecular neurobiology
ISSN: 1573-6830
Titre abrégé: Cell Mol Neurobiol
Pays: United States
ID NLM: 8200709
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
10
04
2020
accepted:
16
12
2020
pubmed:
20
1
2021
medline:
1
6
2022
entrez:
19
1
2021
Statut:
ppublish
Résumé
Rabies virus (RABV) is a neurotropic virus exclusively infecting neurons in the central nervous system. RABV encodes five proteins. Among them, the viral glycoprotein (RVG) plays a key role in viral entry into neurons and rabies pathogenesis. It was shown that the nature of the C-terminus of the RABV G protein, which possesses a PDZ-binding motif (PBM), modulates the virulence of the RABV strain. The neuronal protein partners recruited by this PBM may alter host cell function. This study was conducted to investigate the effect of RVG on synaptic function in the hippocampal dentate gyrus (DG) of rat. Two μl (10
Identifiants
pubmed: 33462779
doi: 10.1007/s10571-020-01032-9
pii: 10.1007/s10571-020-01032-9
doi:
Substances chimiques
Glycoproteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1429-1440Subventions
Organisme : Pasteur Institute of Iran
ID : 868
Informations de copyright
© 2021. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.
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