Does contemporary ART lead to pre-eclampsia? A cohort study and meta-analysis.
Assisted reproductive technology
Fresh embryo transfer
Frozen embryo transfer
Hypertensive disorders of pregnancy
Natural conception
Pre-eclampsia
Journal
Journal of assisted reproduction and genetics
ISSN: 1573-7330
Titre abrégé: J Assist Reprod Genet
Pays: Netherlands
ID NLM: 9206495
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
20
07
2020
accepted:
02
01
2021
pubmed:
20
1
2021
medline:
3
8
2021
entrez:
19
1
2021
Statut:
ppublish
Résumé
Recent publications suggested that the risk for pre-eclampsia (PE) is higher with frozen-thawed embryo transfers (FETs) compared to fresh transfers (IVF-ETs). These studies were based on old data that reflects outdated practices. In this paper, we wanted to assess the incidence of PE in current assisted reproductive technology (ART) practice. In this cohort study, we present the incidence of PE in all births in the province of Ontario, Canada, for the years 2013-2017 for FET, IVF-ET, and natural conceptions (NC). We also compare our findings to previous studies in a meta-analysis that includes over 4 million births. The results of our study show that contemporary practice of ART results in comparable risk for PE between FET and IVF-ET; however, the risk is higher than NC. Current ART practice is associated with a lower risk for PE in frozen embryo transfer; this RR can be further attenuated by using ovulatory endometrial preparation for FETs.
Identifiants
pubmed: 33464436
doi: 10.1007/s10815-021-02061-z
pii: 10.1007/s10815-021-02061-z
pmc: PMC7910335
doi:
Types de publication
Journal Article
Meta-Analysis
Langues
eng
Sous-ensembles de citation
IM
Pagination
651-659Références
Roque M, Valle M, Guimaraes F, Sampaio M, Geber S. Cost-effectiveness of the freeze-all policy. JBRA Assist Reprod. 2015;19(3):125-30. 10.5935/1518-0557.20150028.
Roque M, Haahr T, Geber S, Esteves SC, Humaidan P. Fresh versus elective frozen embryo transfer in IVF/ICSI cycles: a systematic review and meta-analysis of reproductive outcomes. Hum Reprod Update. 2019;25(1):2–14. https://doi.org/10.1093/humupd/dmy033 .
doi: 10.1093/humupd/dmy033
pubmed: 30388233
Maheshwari A, Pandey S, Amalraj Raja E, Shetty A, Hamilton M, Bhattacharya S. Is frozen embryo transfer better for mothers and babies? Can cumulative meta-analysis provide a definitive answer? Hum Reprod Update. 2018;24(1):35–58. https://doi.org/10.1093/humupd/dmx031 .
doi: 10.1093/humupd/dmx031
pubmed: 29155965
Sabban H, Zakhari A, Patenaude V, Tulandi T, Abenhaim HA. Obstetrical and perinatal morbidity and mortality among in-vitro fertilization pregnancies: a population-based study. Arch Gynecol Obstet. 2017;296(1):107–13. https://doi.org/10.1007/s00404-017-4379-8 .
doi: 10.1007/s00404-017-4379-8
pubmed: 28547098
O’Gorman N, Wright D, Poon LC, Rolnik DL, Syngelaki A, Wright A, et al. Accuracy of competing-risks model in screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks’ gestation. Ultrasound Obstet Gynecol. 2017;49(6):751–5. https://doi.org/10.1002/uog.17399 .
doi: 10.1002/uog.17399
pubmed: 28067011
Boulet SL, Mehta A, Kissin DM, Warner L, Kawwass JF, Jamieson DJ. Trends in use of and reproductive outcomes associated with intracytoplasmic sperm injection. JAMA. 2015;313(3):255–63. https://doi.org/10.1001/jama.2014.17985 .
doi: 10.1001/jama.2014.17985
pubmed: 25602996
Glujovsky D, Farquhar C. Cleavage-stage or blastocyst transfer: what are the benefits and harms? Fertil Steril. 2016;106(2):244–50. https://doi.org/10.1016/j.fertnstert.2016.06.029 .
doi: 10.1016/j.fertnstert.2016.06.029
pubmed: 27421614
Levi-Setti PE, Patrizio P, Scaravelli G. Evolution of human oocyte cryopreservation: slow freezing versus vitrification. Curr Opin Endocrinol Diabetes Obes. 2016;23(6):445–50. https://doi.org/10.1097/MED.0000000000000289 .
doi: 10.1097/MED.0000000000000289
pubmed: 27653002
Dunn S, Bottomley J, Ali A, Walker M. 2008 Niday Perinatal Database quality audit: report of a quality assurance project. Chronic Dis Inj Can. 2011;32(1):32–42.
pubmed: 22153174
Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2015;350:g7647. https://doi.org/10.1136/bmj.g7647 .
doi: 10.1136/bmj.g7647
Huedo-Medina TB, Sanchez-Meca J, Marin-Martinez F, Botella J. Assessing heterogeneity in meta-analysis: Q statistic or I2 index? Psychol Methods. 2006;11(2):193–206. https://doi.org/10.1037/1082-989X.11.2.193 .
doi: 10.1037/1082-989X.11.2.193
pubmed: 16784338
Higgins JPTTJ, Chandler J. Cumpston M, Li T. Welch VA Cochrane Handbook for Systematic Reviews of Interventions. Sixth ed. Cochrane: Page MJ; 2019.
Shi W, Xue X, Zhang S, Zhao W, Liu S, Zhou H, et al. Perinatal and neonatal outcomes of 494 babies delivered from 972 vitrified embryo transfers. Fertil Steril. 2012;97(6):1338–42. https://doi.org/10.1016/j.fertnstert.2012.02.051 .
doi: 10.1016/j.fertnstert.2012.02.051
pubmed: 22464083
Liu SY, Teng B, Fu J, Li X, Zheng Y, Sun XX. Obstetric and neonatal outcomes after transfer of vitrified early cleavage embryos. Hum Reprod. 2013;28(8):2093–100. https://doi.org/10.1093/humrep/det104 .
doi: 10.1093/humrep/det104
pubmed: 23569081
Imudia AN, Awonuga AO, Kaimal AJ, Wright DL, Styer AK, Toth TL. Elective cryopreservation of all embryos with subsequent cryothaw embryo transfer in patients at risk for ovarian hyperstimulation syndrome reduces the risk of adverse obstetric outcomes: a preliminary study. Fertil Steril. 2013;99(1):168–73. https://doi.org/10.1016/j.fertnstert.2012.08.060 .
doi: 10.1016/j.fertnstert.2012.08.060
pubmed: 23025881
Ishihara O, Araki R, Kuwahara A, Itakura A, Saito H, Adamson GD. Impact of frozen-thawed single-blastocyst transfer on maternal and neonatal outcome: an analysis of 277,042 single-embryo transfer cycles from 2008 to 2010 in Japan. Fertil Steril. 2014;101(1):128–33. https://doi.org/10.1016/j.fertnstert.2013.09.025 .
doi: 10.1016/j.fertnstert.2013.09.025
pubmed: 24268706
Sazonova A, Kallen K, Thurin-Kjellberg A, Wennerholm UB, Bergh C. Obstetric outcome in singletons after in vitro fertilization with cryopreserved/thawed embryos. Hum Reprod. 2012;27(5):1343–50. https://doi.org/10.1093/humrep/des036 .
doi: 10.1093/humrep/des036
pubmed: 22362926
Opdahl S, Henningsen AA, Tiitinen A, Bergh C, Pinborg A, Romundstad PR, et al. Risk of hypertensive disorders in pregnancies following assisted reproductive technology: a cohort study from the CoNARTaS group. Hum Reprod. 2015;30(7):1724–31. https://doi.org/10.1093/humrep/dev090 .
doi: 10.1093/humrep/dev090
pubmed: 25924655
Ginstrom Ernstad E, Wennerholm UB, Khatibi A, Petzold M, Bergh C. Neonatal and maternal outcome after frozen embryo transfer: increased risks in programmed cycles. Am J Obstet Gynecol. 2019;221(2):126 e1- e18. 10.1016/j.ajog.2019.03.010.
Xiong F, Hu L, Zhang Y, Xiao X. Correlation of hypertensive disorders in pregnancy with procedures of in vitro fertilization and pregnancy outcomes. Exp Ther Med. 2017;14(6):5405–10. https://doi.org/10.3892/etm.2017.5204 .
doi: 10.3892/etm.2017.5204
pubmed: 29285069
pmcid: 5740777
Shavit T, Oron G, Weon-Young S, Holzer H, Tulandi T. Vitrified-warmed single-embryo transfers may be associated with increased maternal complications compared with fresh single-embryo transfers. Reprod Biomed Online. 2017;35(1):94–102. https://doi.org/10.1016/j.rbmo.2017.03.016 .
doi: 10.1016/j.rbmo.2017.03.016
pubmed: 28427857
Sites CK, Wilson D, Barsky M, Bernson D, Bernstein IM, Boulet S, et al. Embryo cryopreservation and preeclampsia risk. Fertil Steril. 2017;108(5):784–90. https://doi.org/10.1016/j.fertnstert.2017.08.035 .
doi: 10.1016/j.fertnstert.2017.08.035
pubmed: 28974308
Johnson KM, Hacker MR, Resetkova N, O’Brien B, Modest AM. Risk of ischemic placental disease in fresh and frozen embryo transfer cycles. Fertil Steril. 2019;111(4):714–21. https://doi.org/10.1016/j.fertnstert.2018.11.043 .
doi: 10.1016/j.fertnstert.2018.11.043
pubmed: 30826115
pmcid: 6443502
Luke B, Brown MB, Eisenberg ML, Callan C, Botting BJ, Pacey A et al. In vitro fertilization and risk for hypertensive disorders of pregnancy: associations with treatment parameters. Am J Obstet Gynecol. 2020;222(4):350 e1- e13. 10.1016/j.ajog.2019.10.003.
Moore RA, Gavaghan DJ, Edwards JE, Wiffen P, McQuay HJ. Pooling data for number needed to treat: no problems for apples. BMC Med Res Methodol. 2002;2:2. https://doi.org/10.1186/1471-2288-2-2 .
doi: 10.1186/1471-2288-2-2
pubmed: 11860605
pmcid: 65633
von Versen-Hoynck F, Schaub AM, Chi YY, Chiu KH, Liu J, Lingis M, et al. Increased preeclampsia risk and reduced aortic compliance with in vitro fertilization cycles in the absence of a corpus luteum. Hypertension. 2019;73(3):640–9. https://doi.org/10.1161/HYPERTENSIONAHA.118.12043 .
doi: 10.1161/HYPERTENSIONAHA.118.12043
Wang Z, Liu H, Song H, Li X, Jiang J, Sheng Y et al. Increased risk of pre-eclampsia after frozen-thawed embryo transfer in programming cycles. Front Med (Lausanne). 2020;7:104. 10.3389/fmed.2020.00104.
Liu KE, Hartman M, Hartman A, Luo ZC, Mahutte N. The impact of a thin endometrial lining on fresh and frozen-thaw IVF outcomes: an analysis of over 40 000 embryo transfers. Hum Reprod. 2018;33(10):1883–8. https://doi.org/10.1093/humrep/dey281 .
doi: 10.1093/humrep/dey281
pubmed: 30239738
pmcid: 6145412
Dayan N, Lanes A, Walker MC, Spitzer KA, Laskin CA. Effect of chronic hypertension on assisted pregnancy outcomes: a population-based study in Ontario. Canada. Fertil Steril. 2016;105(4):1003–9. https://doi.org/10.1016/j.fertnstert.2015.11.039 .
doi: 10.1016/j.fertnstert.2015.11.039
pubmed: 26690007
Rolnik DL, Wright D, Poon LC, O’Gorman N, Syngelaki A, de Paco MC, et al. Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia. N Engl J Med. 2017;377(7):613–22. https://doi.org/10.1056/NEJMoa1704559 .
doi: 10.1056/NEJMoa1704559
pubmed: 28657417