Antibiotics with therapeutic effects on spinal cord injury: a review.
antibiotics
macrolides
neuroprotection
neuroregeneration
spinal cord injury
β-lactams
Journal
Fundamental & clinical pharmacology
ISSN: 1472-8206
Titre abrégé: Fundam Clin Pharmacol
Pays: England
ID NLM: 8710411
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
revised:
06
08
2020
received:
13
02
2020
accepted:
08
09
2020
pubmed:
20
1
2021
medline:
9
10
2021
entrez:
19
1
2021
Statut:
ppublish
Résumé
Accumulating evidence indicates that a considerable number of antibiotics exert anti-inflammatory and neuroprotective effects in different central and peripheral nervous system diseases including spinal cord injury (SCI). Both clinical and preclinical studies on SCI have found therapeutic effects of antibiotics from different families on SCI. These include macrolides, minocycline, β-lactams, and dapsone, all of which have been found to improve SCI sequels and complications. These antibiotics may target similar signaling pathways such as reducing inflammatory microglial activity, promoting autophagy, inhibiting neuronal apoptosis, and modulating the SCI-related mitochondrial dysfunction. In this review paper, we will discuss the mechanisms underlying therapeutic effects of these antibiotics on SCI, which not only could supply vital information for investigators but also guide clinicians to consider administering these antibiotics as part of a multimodal therapeutic approach for management of SCI and its complications.
Substances chimiques
Anti-Bacterial Agents
0
Neuroprotective Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
277-304Informations de copyright
© 2020 Société Française de Pharmacologie et de Thérapeutique.
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