Double Click-Functionalized siRNA Polyplexes for Gene Silencing in Epidermal Growth Factor Receptor-Positive Tumor Cells.

Cell Line, Tumor ErbB Receptors / genetics Gene Silencing Humans RNA, Small Interfering / genetics Transfection
EGF receptor click-chemistry gene silencing shielding siRNA delivery tumor targeting

Journal

ACS biomaterials science & engineering
ISSN: 2373-9878
Titre abrégé: ACS Biomater Sci Eng
Pays: United States
ID NLM: 101654670

Informations de publication

Date de publication:
10 02 2020
Historique:
entrez: 19 1 2021
pubmed: 20 1 2021
medline: 15 5 2021
Statut: ppublish

Résumé

Sequence-defined lipo-oligomers generated via solid-phase assisted synthesis have been developed as siRNA delivery systems for RNA-interference (RNAi) based gene silencing. Here, novel siRNA lipo-polyplexes were established, which were postmodified with monovalent or bivalent DBCO-PEG

Identifiants

DOI: 10.1021/acsbiomaterials.9b01904 PMID: 33464867
pubmed: 33464867
doi: 10.1021/acsbiomaterials.9b01904
doi:

Substances chimiques

RNA, Small Interfering 0
ErbB Receptors EC 2.7.10.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1074-1089

Auteurs

Yanfang Wang (Y)

Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, Butenandtstrasse 5-13, 81377 Munich, Germany.
ORCID: 0000-0002-7989-5323

Jie Luo (J)

Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, Butenandtstrasse 5-13, 81377 Munich, Germany.

Ines Truebenbach (I)

Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, Butenandtstrasse 5-13, 81377 Munich, Germany.
ORCID: 0000-0003-1476-4872

Sören Reinhard (S)

Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, Butenandtstrasse 5-13, 81377 Munich, Germany.
ORCID: 0000-0003-1348-5919

Philipp Michael Klein (PM)

Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, Butenandtstrasse 5-13, 81377 Munich, Germany.

Miriam Höhn (M)

Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, Butenandtstrasse 5-13, 81377 Munich, Germany.

Sarah Kern (S)

Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, Butenandtstrasse 5-13, 81377 Munich, Germany.

Stephan Morys (S)

Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, Butenandtstrasse 5-13, 81377 Munich, Germany.

Dominik M Loy (DM)

Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, Butenandtstrasse 5-13, 81377 Munich, Germany.

Ernst Wagner (E)

Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, Butenandtstrasse 5-13, 81377 Munich, Germany.
Nanosystems Initiative Munich (NIM), Schellingstrasse 4, 80799 Munich, Germany.
ORCID: 0000-0001-8413-0934

Wei Zhang (W)

Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, Butenandtstrasse 5-13, 81377 Munich, Germany.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Double Click-Functionalized siRNA Polyplexes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs ErbB › Double Click-Functionalized siRNA Polyplexes...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Double Click-Functionalized siRNA Polyplexes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Double Click-Functionalized siRNA Polyplexes...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › Petit ARN interférent › Double Click-Functionalized siRNA Polyplexes...
questionsmedicales.fr › Phénomènes génétiques › Recombinaison génétique › Transfection › Double Click-Functionalized siRNA Polyplexes...