Fighting the storm: could novel anti-TNFα and anti-IL-6
Anti-Inflammatory Agents
/ pharmacology
COVID-19
/ complications
Cannabinoids
/ pharmacology
Cannabis
Cell Line
Cytokine Release Syndrome
Fibroblasts
/ drug effects
Humans
Inflammation
/ virology
Interleukin-6
/ antagonists & inhibitors
Plant Extracts
/ pharmacology
SARS-CoV-2
Skin
/ drug effects
Tissue Culture Techniques
Tumor Necrosis Factor-alpha
/ antagonists & inhibitors
COVID-19
IL-6
SARS-CoV2
TNFα
cytokine storm
fibrosis
medical cannabis
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
19 01 2021
19 01 2021
Historique:
received:
19
05
2020
accepted:
13
11
2020
pubmed:
20
1
2021
medline:
12
2
2021
entrez:
19
1
2021
Statut:
ppublish
Résumé
The main aspects of severe COVID-19 disease pathogenesis include hyper-induction of proinflammatory cytokines, also known as 'cytokine storm', that precedes acute respiratory distress syndrome (ARDS) and often leads to death. COVID-19 patients often suffer from lung fibrosis, a serious and untreatable condition. There remains no effective treatment for these complications. Out of all cytokines, TNFα and IL-6 play crucial roles in cytokine storm pathogenesis and are likely responsible for the escalation in disease severity. These cytokines also partake in the molecular pathogenesis of fibrosis. Therefore, new approaches are urgently needed, that can efficiently and swiftly downregulate TNFα, IL-6, and the inflammatory cytokine cascade, in order to curb inflammation and prevent fibrosis, and lead to disease remission.
Identifiants
pubmed: 33465050
pii: 202500
doi: 10.18632/aging.202500
pmc: PMC7880317
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Cannabinoids
0
IL6 protein, human
0
Interleukin-6
0
Plant Extracts
0
TNF protein, human
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1571-1590Références
Pharmacotherapy. 2020 May;40(5):484-486
pubmed: 32267560
Thorax. 2017 Aug;72(8):746-759
pubmed: 28416592
BMC Bioinformatics. 2009 May 27;10:161
pubmed: 19473525
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Biomed Pharmacother. 2020 Nov;131:110698
pubmed: 32920514
Am J Respir Cell Mol Biol. 2007 Jul;37(1):121-8
pubmed: 17379849
J Am Heart Assoc. 2015 Aug 24;4(8):e002128
pubmed: 26304941
PLoS One. 2008 May 14;3(5):e2142
pubmed: 18478089
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
Yeast. 2000 Apr;17(1):48-55
pubmed: 10928937
J Med Virol. 2005 Feb;75(2):185-94
pubmed: 15602737
Int J Antimicrob Agents. 2020 May;55(5):105954
pubmed: 32234467
Transplant Proc. 2020 Nov;52(9):2711-2714
pubmed: 32563584
J Clin Invest. 2004 Aug;114(3):438-46
pubmed: 15286810
Mil Med Res. 2020 Mar 13;7(1):11
pubmed: 32169119
Lancet Rheumatol. 2020 May;2(5):e255-e256
pubmed: 32368737
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
Immunology. 2012 Feb;135(2):112-24
pubmed: 22044352
Cureus. 2020 Apr 6;12(4):e7560
pubmed: 32269893
Genome Biol. 2014;15(12):550
pubmed: 25516281
Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5455-60
pubmed: 25870276
Lancet. 2020 May 2;395(10234):1407-1409
pubmed: 32278362
J Transl Med. 2020 Apr 14;18(1):165
pubmed: 32290847
J Pathol. 2008 Jan;214(2):199-210
pubmed: 18161745
Front Med (Lausanne). 2019 Jan 14;5:364
pubmed: 30693283
Hellenic J Cardiol. 2020 Jan - Feb;61(1):42-45
pubmed: 32251729
Gerontology. 2020;66(2):209-210
pubmed: 31505500
Immunol Rev. 2018 Jan;281(1):8-27
pubmed: 29247995
Life Sci. 2019 Sep 15;233:116671
pubmed: 31336122
Life Sci. 2020 Jun 1;250:117583
pubmed: 32217117
Immunotherapy. 2016 Jul;8(8):959-70
pubmed: 27381687
Ann Rheum Dis. 2021 May;80(5):e62
pubmed: 32546603
Am J Pathol. 2005 Mar;166(3):675-84
pubmed: 15743780
J Clin Invest. 2020 May 1;130(5):2202-2205
pubmed: 32217834
Br J Pharmacol. 2011 Aug;163(7):1344-64
pubmed: 21749363
J Biol Regul Homeost Agents. 2020 Mar 14;34(2):327-331
pubmed: 32171193
Semin Immunopathol. 2017 Jul;39(5):529-539
pubmed: 28466096
Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7809-14
pubmed: 18490652
Bioinformatics. 2013 Jul 15;29(14):1830-1
pubmed: 23740750
PLoS Pathog. 2013;9(8):e1003520
pubmed: 23935498
Clin Pharmacol Ther. 2021 Mar;109(3):688-696
pubmed: 33210302
Chin Med J (Engl). 2020 Jun 20;133(12):1390-1396
pubmed: 32251003
Arch Acad Emerg Med. 2020 Mar 30;8(1):e40
pubmed: 32259129
J Clin Invest. 2007 Mar;117(3):524-9
pubmed: 17332879
Nat Methods. 2015 Apr;12(4):357-60
pubmed: 25751142
J Transl Med. 2020 Apr 14;18(1):164
pubmed: 32290839
Wien Med Wochenschr. 2015 Jan;165(1-2):3-9
pubmed: 25651945
PLoS One. 2006 Dec 27;1:e108
pubmed: 17205112
Cell Mol Immunol. 2016 Jan;13(1):3-10
pubmed: 26189369
Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a001651
pubmed: 20457564
Am J Respir Cell Mol Biol. 2016 Sep;55(3):309-22
pubmed: 27149613
Nat Rev Endocrinol. 2018 Oct;14(10):576-590
pubmed: 30046148
Inflammation. 2004 Dec;28(6):359-64
pubmed: 16245079
J Autoimmun. 2020 Jul;111:102468
pubmed: 32317220
Rev Med Virol. 2020 Nov;30(6):1-9
pubmed: 32845568
J Med Virol. 2020 Apr;92(4):424-432
pubmed: 31981224
Nat Rev Immunol. 2020 Jun;20(6):363-374
pubmed: 32346093
Am J Respir Crit Care Med. 2014 Jul 15;190(2):185-95
pubmed: 24921217
Shock. 2014 Sep;42(3):246-55
pubmed: 24978886
Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L6-L16
pubmed: 28860146
Clin Sci (Lond). 2016 Jul 1;130(14):1237-46
pubmed: 27129183