Comparison of efficacy and safety of complementary and alternative therapies for primary trigeminal neuralgia: A protocol for a Bayesian network meta analysis.
Journal
Medicine
ISSN: 1536-5964
Titre abrégé: Medicine (Baltimore)
Pays: United States
ID NLM: 2985248R
Informations de publication
Date de publication:
15 Jan 2021
15 Jan 2021
Historique:
received:
07
12
2020
accepted:
15
12
2020
entrez:
20
1
2021
pubmed:
21
1
2021
medline:
27
1
2021
Statut:
ppublish
Résumé
Primary trigeminal neuralgia (PTN) is a type of peripheral neuralgia that seriously affects people's lives. In recent years, complementary therapies and alternative therapies have played a significant role in treating PTN. However, there is a lack of comparison among all the complementary and alternative therapies at present. Thus, the aim of this study is to discuss the efficacy and safety of diverse complementary and alternative therapies by Bayesian network meta-analysis (NMA). We will retrieve the Chinese and English databases to gather related randomized controlled trials (RCTs) of complementary and alternative therapies for treating PTN. The deadline is November 2020. Two independent researchers will be in charge of screening qualified literature, extracting data, and independently evaluating bias risks involved in the research. Pairwise meta-analysis and Bayesian network meta-analysis will be performed to assess all evidence. Then, we will use STATA16.0 as well as WinBUGS1.4.3 software for data analysis. Besides, the quality of NMA evidence will be classified by grading of recommendations assessment development and evaluation (GRADE). This study will compare and rank the efficacy and safety of different complementary and alternative therapies in treating primary trigeminal neuralgia. Complementary and alternative therapies play an essential role in treating primary trigeminal neuralgia. We expect our study will furnish meaningful evidence support for clinicians and patients. INPLASY2020120026. Since the study is based on published or registered RCTs, ethical approval and patient informed consent are abandoned.
Sections du résumé
BACKGROUND
BACKGROUND
Primary trigeminal neuralgia (PTN) is a type of peripheral neuralgia that seriously affects people's lives. In recent years, complementary therapies and alternative therapies have played a significant role in treating PTN. However, there is a lack of comparison among all the complementary and alternative therapies at present. Thus, the aim of this study is to discuss the efficacy and safety of diverse complementary and alternative therapies by Bayesian network meta-analysis (NMA).
METHODS
METHODS
We will retrieve the Chinese and English databases to gather related randomized controlled trials (RCTs) of complementary and alternative therapies for treating PTN. The deadline is November 2020. Two independent researchers will be in charge of screening qualified literature, extracting data, and independently evaluating bias risks involved in the research. Pairwise meta-analysis and Bayesian network meta-analysis will be performed to assess all evidence. Then, we will use STATA16.0 as well as WinBUGS1.4.3 software for data analysis. Besides, the quality of NMA evidence will be classified by grading of recommendations assessment development and evaluation (GRADE).
RESULTS
RESULTS
This study will compare and rank the efficacy and safety of different complementary and alternative therapies in treating primary trigeminal neuralgia.
CONCLUSION
CONCLUSIONS
Complementary and alternative therapies play an essential role in treating primary trigeminal neuralgia. We expect our study will furnish meaningful evidence support for clinicians and patients.
PROTOCOL REGISTRATION NUMBER
UNASSIGNED
INPLASY2020120026.
ETHICAL APPROVAL
UNASSIGNED
Since the study is based on published or registered RCTs, ethical approval and patient informed consent are abandoned.
Identifiants
pubmed: 33466199
doi: 10.1097/MD.0000000000024212
pii: 00005792-202101150-00082
pmc: PMC7808446
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e24212Subventions
Organisme : Key Technology Research and Development Program of Shandong
ID : 2018GSF119021
Informations de copyright
Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to disclose.
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