Temporomandibular Joint Osteoarthritis: Regenerative Treatment by a Stem Cell Containing Advanced Therapy Medicinal Product (ATMP)-An In Vivo Animal Trial.
Animals
Female
Male
Rabbits
Cartilage, Articular
/ metabolism
Hyaluronic Acid
/ metabolism
Injections, Intra-Articular
/ methods
Mesenchymal Stem Cells
/ cytology
Osteoarthritis
/ metabolism
Regeneration
/ physiology
Stem Cells
/ cytology
Temporomandibular Joint
/ metabolism
Temporomandibular Joint Disorders
/ metabolism
TMJD
osteoarthritis
regenerative medicine
regenerative therapy
stem cell therapy
temporomandibular joint
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
05 Jan 2021
05 Jan 2021
Historique:
received:
30
11
2020
revised:
28
12
2020
accepted:
29
12
2020
entrez:
20
1
2021
pubmed:
21
1
2021
medline:
7
4
2021
Statut:
epublish
Résumé
Temporomandibular joint osteoarthritis (TMJ-OA) is a chronic degenerative disease that is often characterized by progressive impairment of the temporomandibular functional unit. The aim of this randomized controlled animal trial was a comparative analysis regarding the chondroregenerative potency of intra-articular stem/stromal cell therapy. Four weeks after combined mechanical and biochemical osteoarthritis induction in 28 rabbits, therapy was initiated by a single intra-articular injection, randomized into the following groups: Group 1: AB Serum (ABS); Group 2: Hyaluronic acid (HA); Group 3: Mesenchymal stromal cells (STx.); Group 4: Mesenchymal stromal cells in hyaluronic acid (HA + STx.). After another 4 weeks, the animals were euthanized, followed by histological examination of the removed joints. The histological analysis showed a significant increase in cartilage thickness in the stromal cell treated groups (HA + STx. vs. ABS,
Identifiants
pubmed: 33466246
pii: ijms22010443
doi: 10.3390/ijms22010443
pmc: PMC7795212
pii:
doi:
Substances chimiques
Hyaluronic Acid
9004-61-9
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Bundesministerium für Wirtschaft und Energie
ID : KF 3259803CR4
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