Allogeneic Stem Cell Transplantation in Mantle Cell Lymphoma in the Era of New Drugs and CAR-T Cell Therapy.

Car-T cell therapy allogeneic stem cell transplantation mantle cell lymphoma

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
14 Jan 2021
Historique:
received: 11 12 2020
revised: 08 01 2021
accepted: 11 01 2021
entrez: 20 1 2021
pubmed: 21 1 2021
medline: 21 1 2021
Statut: epublish

Résumé

MCL is an uncommon lymphoproliferative disorder that has been regarded as incurable since its identification as a distinct entity. Allogeneic transplantation for two decades has represented the only option capable of ensuring prolonged remissions and possibly cure. Despite its efficacy, its application has been limited by feasibility limitations and substantial toxicity, particularly in elderly patients. Nevertheless, the experience accumulated over time has been wide though often scattered among retrospective and small prospective studies. In this review, we aimed at critically revise and discuss available evidence on allogeneic transplantation in MCL, trying to put available evidence into the 2020 perspective, characterized by unprecedented development of novel promising therapeutic agents and regimens.

Identifiants

pubmed: 33466784
pii: cancers13020291
doi: 10.3390/cancers13020291
pmc: PMC7830938
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Subventions

Organisme : Mattioli 1885
ID : N/A
Organisme : Cilag
ID : N/A

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Auteurs

Miriam Marangon (M)

Department of Hematology, Azienda Sanitaria Universitaria Giuliano Isontina, 34129 Trieste, Italy.

Carlo Visco (C)

Section of Hematology, Department of Medicine, University of Verona, 37134 Verona, Italy.

Anna Maria Barbui (AM)

Hematology Unit, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy.

Annalisa Chiappella (A)

Division of Hematology, Fondazione IRCCS, Istituto Nazionale dei Tumori, 20133 Milan, Italy.

Alberto Fabbri (A)

Hematology Division, Department of Oncology, Azienda Ospedaliero-Universitaria Senese, 53100 Siena, Italy.

Simone Ferrero (S)

Hematology Division, Department of Molecular Biotechnologies and Health Sciences, Università di Torino, 10126 Torino, Italy.
Hematology 1, AOU Città della Salute e della Scienza di Torino, 10126 Torino, Italy.

Sara Galimberti (S)

Hematology Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.

Stefano Luminari (S)

Hematology Unit, Azienda Unità Sanitaria Locale IRCCS di Reggio Emilia, 42123 Modena, Italy.
Surgical, Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, 42123 Modena, Italy.

Gerardo Musuraca (G)

Department of Hematology, IRCCS-Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (I.R.S.T.), 47014 Meldola, Italy.

Alessandro Re (A)

Hematology Unit, ASST Spedali Civili, 25123 Brescia, Italy.

Vittorio Ruggero Zilioli (VR)

Division of Hematology, ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy.

Marco Ladetto (M)

SC Ematologia, Azienda Ospedaliera Santi Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.
Dipartimento di Medicina Traslazionale, Università del Piemonte Orientale, 15121 Alessandria, Italy.

Classifications MeSH