Matching Clinical Diagnosis and Amyloid Biomarkers in Alzheimer's Disease and Frontotemporal Dementia.
Alzheimer’s disease
CSF biomarkers
amyloid-PET
frontotemporal dementia
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
14 Jan 2021
14 Jan 2021
Historique:
received:
01
12
2020
revised:
08
01
2021
accepted:
09
01
2021
entrez:
20
1
2021
pubmed:
21
1
2021
medline:
21
1
2021
Statut:
epublish
Résumé
The aims of this study were to compare the diagnostic accuracy, sensitivity, specificity, and positive and negative predictive values (PPV, NPV) of different cerebrospinal fluid (CSF) amyloid biomarkers and amyloid-Positron Emission Tomography (PET) in patients with a clinical diagnosis of Alzheimer's disease (AD) and Frontotemporal Dementia (FTD); to compare concordance between biomarkers; and to provide an indication of their use and interpretation. We included 148 patients (95 AD and 53 FTD), who underwent clinical evaluation, neuropsychological assessment, and at least one amyloid biomarker (CSF analysis or amyloid-PET). Thirty-six patients underwent both analyses. One-hundred-thirteen patients underwent Apolipoprotein E (ApoE) genotyping. Amyloid-PET presented higher diagnostic accuracy, sensitivity, and NPV than CSF Aβ CSF Aβ
Sections du résumé
BACKGROUND
BACKGROUND
The aims of this study were to compare the diagnostic accuracy, sensitivity, specificity, and positive and negative predictive values (PPV, NPV) of different cerebrospinal fluid (CSF) amyloid biomarkers and amyloid-Positron Emission Tomography (PET) in patients with a clinical diagnosis of Alzheimer's disease (AD) and Frontotemporal Dementia (FTD); to compare concordance between biomarkers; and to provide an indication of their use and interpretation.
METHODS
METHODS
We included 148 patients (95 AD and 53 FTD), who underwent clinical evaluation, neuropsychological assessment, and at least one amyloid biomarker (CSF analysis or amyloid-PET). Thirty-six patients underwent both analyses. One-hundred-thirteen patients underwent Apolipoprotein E (ApoE) genotyping.
RESULTS
RESULTS
Amyloid-PET presented higher diagnostic accuracy, sensitivity, and NPV than CSF Aβ
CONCLUSIONS
CONCLUSIONS
CSF Aβ
Identifiants
pubmed: 33466854
pii: jpm11010047
doi: 10.3390/jpm11010047
pmc: PMC7830228
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fondazione Cassa di Risparmio di Firenze
ID : ECRF16 - CONTRIBUTO 2015.0713, SORBI
Organisme : Ateneo dell'Università di Firenze
ID : fondi Ateneo 2020, Sorbi and Nacmias
Références
PLoS One. 2012;7(2):e31084
pubmed: 22328928
Neurol Ther. 2017 Jul;6(Suppl 1):15-24
pubmed: 28733960
Brain. 2015 Mar;138(Pt 3):514-6
pubmed: 25713403
J Alzheimers Dis. 2015;45(4):1077-88
pubmed: 25649653
Brain. 2016 Sep;139(Pt 9):2540-53
pubmed: 27401520
Alzheimers Dement. 2011 May;7(3):263-9
pubmed: 21514250
Alzheimers Dement. 2011 May;7(3):280-92
pubmed: 21514248
Brain. 2006 Nov;129(Pt 11):3035-41
pubmed: 17012293
Alzheimers Dement. 2015 Aug;11(8):964-74
pubmed: 25824567
Trends Pharmacol Sci. 2015 May;36(5):297-309
pubmed: 25840462
Neurology. 2016 Jan 5;86(1):50-8
pubmed: 26468410
Alzheimers Dement. 2018 Apr;14(4):535-562
pubmed: 29653606
Lancet Neurol. 2012 Aug;11(8):669-78
pubmed: 22749065
Lancet Neurol. 2012 Dec;11(12):1048-56
pubmed: 23137948
Ital J Neurol Sci. 1996 Aug;17(4):305-9
pubmed: 8915764
Brain. 2008 Jun;131(Pt 6):1630-45
pubmed: 18339640
JAMA. 2011 Jan 19;305(3):275-83
pubmed: 21245183
EMBO Mol Med. 2009 Nov;1(8-9):371-80
pubmed: 20049742
Alzheimers Dement. 2011 May;7(3):270-9
pubmed: 21514249
Neurosci Lett. 1994 Aug 15;177(1-2):100-2
pubmed: 7824157
Brain. 2007 Oct;130(Pt 10):2636-45
pubmed: 17898010
Lancet Neurol. 2020 Nov;19(11):951-962
pubmed: 33098804
J Neurol Sci. 2018 Sep 15;392:34-37
pubmed: 30097151
Curr Alzheimer Res. 2010 Aug;7(5):470-6
pubmed: 20043812
Brain. 2011 Sep;134(Pt 9):2565-81
pubmed: 21908872
Neurol Sci. 2002 Mar;22(6):443-7
pubmed: 11976975
Neurology. 1998 Dec;51(6):1546-54
pubmed: 9855500
Brain. 2015 Mar;138(Pt 3):772-83
pubmed: 25541191
Ital J Neurol Sci. 1987 Dec;Suppl 8:1-120
pubmed: 3330072
Sci Transl Med. 2013 Jun 12;5(189):189ra77
pubmed: 23761040
Ann Intern Med. 2020 May 19;172(10):669-677
pubmed: 32340038
Lancet Neurol. 2014 Jun;13(6):614-29
pubmed: 24849862
Neurology. 2011 Mar 15;76(11):1006-14
pubmed: 21325651
Neuropsychology. 1997 Apr;11(2):187-94
pubmed: 9110326
J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62
pubmed: 14399272
Neurobiol Aging. 2004 Mar;25(3):273-81
pubmed: 15123331
Ann Neurol. 2018 Nov;84(5):729-740
pubmed: 30255971
Arch Neurol. 2009 Mar;66(3):382-9
pubmed: 19273758
Neurology. 2012 Jul 17;79(3):229-36
pubmed: 22700814
Neurology. 2009 Oct 13;73(15):1193-9
pubmed: 19822868
J Alzheimers Dis. 2013;36(1):67-77
pubmed: 23524657
Ann Clin Transl Neurol. 2019 Sep;6(9):1815-1824
pubmed: 31464088
Brain. 2018 Jul 1;141(7):2181-2193
pubmed: 29878075
J Alzheimers Dis. 2013;36(4):759-67
pubmed: 23666174
Ann Neurol. 2013 Dec;74(6):826-36
pubmed: 23536396
J Alzheimers Dis. 2020;74(2):473-490
pubmed: 32039853
Brain. 2016 Apr;139(Pt 4):1226-36
pubmed: 26936941
Neurology. 2015 Oct 6;85(14):1240-9
pubmed: 26354982
Ann Neurol. 2006 Jan;59(1):156-65
pubmed: 16374817
J Proteome Res. 2006 Apr;5(4):1010-6
pubmed: 16602710
Neurology. 1984 Jul;34(7):939-44
pubmed: 6610841
Alzheimers Res Ther. 2018 Mar 20;10(1):32
pubmed: 29558979
Alzheimers Res Ther. 2019 Dec 7;11(1):100
pubmed: 31810489
Neurology. 2011 Dec 6;77(23):2034-42
pubmed: 22131541
Alzheimers Dement. 2018 Oct;14(10):1313-1333
pubmed: 29940161
Lancet. 2016 Jul 30;388(10043):505-17
pubmed: 26921134
Neuroreport. 1997 Dec 22;8(18):3961-3
pubmed: 9462474
J Neurol Neurosurg Psychiatry. 1999 Feb;66(2):184-8
pubmed: 10071097
Mult Scler. 2009 Apr;15(4):448-54
pubmed: 19153172
J Nucl Med. 2016 Aug;57(8):1316-22
pubmed: 27481605
Cerebrospinal Fluid Res. 2010 Jul 30;7:10
pubmed: 20673341
J Alzheimers Dis. 2016 Oct 18;54(4):1297-1302
pubmed: 27567830
Eur J Nucl Med Mol Imaging. 2020 Feb;47(2):270-280
pubmed: 31388720
JAMA Neurol. 2015 Mar;72(3):287-94
pubmed: 25622185
Ann Clin Transl Neurol. 2014 Aug;1(8):534-43
pubmed: 25356425
Alzheimers Res Ther. 2019 Apr 22;11(1):34
pubmed: 31010420
Neurobiol Aging. 2020 Dec;96:155-164
pubmed: 33010672
JAMA. 2015 May 19;313(19):1939-49
pubmed: 25988463
Neurology. 2003 Feb 25;60(4):652-6
pubmed: 12601108
Eur J Nucl Med Mol Imaging. 2016 Feb;43(2):374-385
pubmed: 26613792
J Psychiatr Res. 1990;24(3):213-26
pubmed: 2266510
Alzheimers Res Ther. 2019 Sep 12;11(1):78
pubmed: 31511058