Structural Insights into Membrane Fusion Mediated by Convergent Small Fusogens.
Amino Acid Motifs
Animals
Bacteriophages
/ metabolism
Cell Fusion
Cell Membrane
/ metabolism
GTP-Binding Proteins
/ metabolism
Humans
Hydrophobic and Hydrophilic Interactions
Inflammation
Membrane Fusion
Membrane Proteins
/ metabolism
Mice
Muscle, Skeletal
/ metabolism
Mutation
Myoblasts
/ metabolism
Protein Domains
Protein Structure, Secondary
FAST
SNARE
atlastin
fusogen
membrane fusion
myomaker
myomerger
spanin
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
15 01 2021
15 01 2021
Historique:
received:
19
10
2020
revised:
07
01
2021
accepted:
13
01
2021
entrez:
20
1
2021
pubmed:
21
1
2021
medline:
9
7
2021
Statut:
epublish
Résumé
From lifeless viral particles to complex multicellular organisms, membrane fusion is inarguably the important fundamental biological phenomena. Sitting at the heart of membrane fusion are protein mediators known as fusogens. Despite the extensive functional and structural characterization of these proteins in recent years, scientists are still grappling with the fundamental mechanisms underlying membrane fusion. From an evolutionary perspective, fusogens follow divergent evolutionary principles in that they are functionally independent and do not share any sequence identity; however, they possess structural similarity, raising the possibility that membrane fusion is mediated by essential motifs ubiquitous to all. In this review, we particularly emphasize structural characteristics of small-molecular-weight fusogens in the hope of uncovering the most fundamental aspects mediating membrane-membrane interactions. By identifying and elucidating fusion-dependent functional domains, this review paves the way for future research exploring novel fusogens in health and disease.
Identifiants
pubmed: 33467484
pii: cells10010160
doi: 10.3390/cells10010160
pmc: PMC7830690
pii:
doi:
Substances chimiques
MYMX protein, human
0
Membrane Proteins
0
ATL1 protein, human
EC 3.6.1.-
GTP-Binding Proteins
EC 3.6.1.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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