The impact of ageing and sex on sympathetic neurocirculatory regulation.
Ageing
Blood pressure
Microneurography
Muscle sympathetic nerve activity
Neural control of the circulation
Neurovascular transduction
Sex differences
Journal
Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
15
11
2020
revised:
30
12
2020
accepted:
04
01
2021
pubmed:
21
1
2021
medline:
9
2
2022
entrez:
20
1
2021
Statut:
ppublish
Résumé
The sympathetic nervous system represents a critical mechanism for homoeostatic blood pressure regulation in humans. This review focuses on age-related alterations in neurocirculatory regulation in men and women by highlighting human studies that examined the relationship between muscle sympathetic nerve activity (MSNA) acquired by microneurography and circulatory variables (e.g., blood pressure, vascular resistance). We frame this review with epidemiological evidence highlighting sex-specific patterns in age-related blood pressure increases in developed nations. Indeed, young women exhibit lower blood pressure than men, but women demonstrate larger blood pressure increases with age, such that by about age 60 years, blood pressure is greater in women. Sympathetic neurocirculatory mechanisms contribute to sex differences in blood pressure rises with age. Muscle sympathetic nerve activity increases with age in both sexes, but women demonstrate greater age-related increases. The circulatory adjustments imposed by MSNA - referred to as neurovascular transduction or autonomic (sympathetic) support of blood pressure - differ in men and women. For example, whereas young men demonstrate a positive relationship between resting MSNA and vascular resistance, this relationship is absent in young women due to beta-2 adrenergic vasodilation, which offsets alpha-adrenergic vasoconstriction. However, post-menopausal women demonstrate a positive relationship between MSNA and vascular resistance due to a decline in beta-2 adrenergic vasodilatory mechanisms. Emerging data suggest that greater aerobic fitness appears to modulate neurocirculatory regulation, at least in young, healthy men and women. This review also highlights recent advances in microneurographic recordings of sympathetic action potential discharge, which may nuance our understanding of age-related alterations in sympathetic neurocirculatory regulation in humans.
Identifiants
pubmed: 33468420
pii: S1084-9521(21)00001-X
doi: 10.1016/j.semcdb.2021.01.001
pmc: PMC8282778
mid: NIHMS1660513
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
72-81Subventions
Organisme : NHLBI NIH HHS
ID : R35 HL139854
Pays : United States
Organisme : NIA NIH HHS
ID : U54 AG044170
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
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