Engulfed by Glia: Glial Pruning in Development, Function, and Injury across Species.
glia
model organisms
neuronal pruning
phagocytosis
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
03 02 2021
03 02 2021
Historique:
received:
30
06
2020
revised:
20
10
2020
accepted:
26
10
2020
pubmed:
21
1
2021
medline:
29
4
2021
entrez:
20
1
2021
Statut:
ppublish
Résumé
Phagocytic activity of glial cells is essential for proper nervous system sculpting, maintenance of circuitry, and long-term brain health. Glial engulfment of apoptotic cells and superfluous connections ensures that neuronal connections are appropriately refined, while clearance of damaged projections and neurotoxic proteins in the mature brain protects against inflammatory insults. Comparative work across species and cell types in recent years highlights the striking conservation of pathways that govern glial engulfment. Many signaling cascades used during developmental pruning are re-employed in the mature brain to "fine tune" synaptic architecture and even clear neuronal debris following traumatic events. Moreover, the neuron-glia signaling events required to trigger and perform phagocytic responses are impressively conserved between invertebrates and vertebrates. This review offers a compare-and-contrast portrayal of recent findings that underscore the value of investigating glial engulfment mechanisms in a wide range of species and contexts.
Identifiants
pubmed: 33468571
pii: JNEUROSCI.1660-20.2020
doi: 10.1523/JNEUROSCI.1660-20.2020
pmc: PMC7880271
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
823-833Subventions
Organisme : NIA NIH HHS
ID : T32 AG066574
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY026215
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH119349
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS117934
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS114222
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS072212
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS107771
Pays : United States
Informations de copyright
Copyright © 2021 the authors.
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