The p.E152K-STIM1 mutation deregulates Ca

Calcium / metabolism Calcium Signaling / genetics Endoplasmic Reticulum / genetics HEK293 Cells Humans Mutation / genetics Neoplasm Proteins / genetics ORAI1 Protein / metabolism Pancreatitis, Chronic / genetics Stromal Interaction Molecule 1 / genetics
Ca2+ signaling Missense mutation Modifier variant Pancreatitis STIM1 Trypsin secretion

Journal

Journal of cell science
ISSN: 1477-9137
Titre abrégé: J Cell Sci
Pays: England
ID NLM: 0052457

Informations de publication

Date de publication:
10 02 2021
Historique:
received: 24 01 2020
accepted: 24 12 2020
pubmed: 21 1 2021
medline: 13 7 2021
entrez: 20 1 2021
Statut: epublish

Résumé

Since deregulation of intracellular Ca

Identifiants

DOI: 10.1242/jcs.244012 PMID: 33468626
pubmed: 33468626
pii: jcs.244012
doi: 10.1242/jcs.244012
pii:
doi:

Substances chimiques

Neoplasm Proteins 0
ORAI1 Protein 0
STIM1 protein, human 0
Stromal Interaction Molecule 1 0
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : CIHR
Pays : Canada

Informations de copyright

© 2021. Published by The Company of Biologists Ltd.

Déclaration de conflit d'intérêts

Competing interestsThe authors declare no competing or financial interests.

Auteurs

Miguel Burgos (M)

Université de Brest, INSERM, EFS, UMR 1078, GGB, F-29200 Brest, France Mburgoslozano@sescam.jccm.es olivier.mignen@univ-brest.fr.
Centro Regional de Investigaciones Biomédicas (CRIB) and Facultad de Medicina de Albacete, Universidad de Castilla-La Mancha, 02002 Albacete, Spain.
Complejo Hospitalario Universitario de Albacete (UI-CHUA), 02002 Albacete, Spain.
ORCID: 0000-0001-6674-0798

Reginald Philippe (R)

Université de Brest, INSERM, EFS, UMR 1078, GGB, F-29200 Brest, France.

Fabrice Antigny (F)

Univ. Paris-Sud, Faculté de Médecine, Université Paris-Saclay, 94270 Le Kremlin Bicêtre, France.
Inserm UMR_S 999, Hôpital Marie Lannelongue, 92350 Le Plessis Robinson, France.
Department of Cell Physiology and Metabolism, Geneva Medical Center, CH-1211 Geneva, Switzerland.

Paul Buscaglia (P)

Université de Brest, INSERM, EFS, UMR 1078, GGB, F-29200 Brest, France.
UMR1227, Lymphocytes B et Autoimmunité, Université de Brest, INSERM, CHU de Brest, BP824, F29609 Brest, France.

Emmanuelle Masson (E)

Université de Brest, INSERM, EFS, UMR 1078, GGB, F-29200 Brest, France.

Sreya Mukherjee (S)

Department of Chemistry, University of South Florida, Tampa, FL 33620, USA.

Pauline Dubar (P)

Université de Brest, INSERM, EFS, UMR 1078, GGB, F-29200 Brest, France.

Cédric Le Maréchal (C)

Université de Brest, INSERM, EFS, UMR 1078, GGB, F-29200 Brest, France.

Florence Campeotto (F)

Hôpital Necker, AP-HP, Service de Gastroentérologie et Explorations Fonctionnelles Digestives Pédiatriques, Paris Descartes-Sorbonne Paris Cité Université, Institut Imagine, 75015 Paris, France.

Nicolas Lebonvallet (N)

Laboratory of Interactions Keratinocytes Neurons (EA4685), University of Western Brittany, F-29200 Brest, France.

Maud Frieden (M)

Department of Cell Physiology and Metabolism, Geneva Medical Center, CH-1211 Geneva, Switzerland.

Juan Llopis (J)

Centro Regional de Investigaciones Biomédicas (CRIB) and Facultad de Medicina de Albacete, Universidad de Castilla-La Mancha, 02002 Albacete, Spain.

Beatriz Domingo (B)

Centro Regional de Investigaciones Biomédicas (CRIB) and Facultad de Medicina de Albacete, Universidad de Castilla-La Mancha, 02002 Albacete, Spain.

Peter B Stathopulos (PB)

Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, London, ON N6A 5C1, Canada.

Mitsuhiko Ikura (M)

Department of Medical Biophysics, University of Toronto, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.

Wesley Brooks (W)

Department of Chemistry, University of South Florida, Tampa, FL 33620, USA.

Wayne Guida (W)

Department of Chemistry, University of South Florida, Tampa, FL 33620, USA.

Jian-Min Chen (JM)

Université de Brest, INSERM, EFS, UMR 1078, GGB, F-29200 Brest, France.
ORCID: 0000-0002-2424-3969

Claude Ferec (C)

Université de Brest, INSERM, EFS, UMR 1078, GGB, F-29200 Brest, France.

Thierry Capiod (T)

INSERM Unit 1151, Institut Necker Enfants Malades (INEM), Université Paris Descartes, Paris 75014, France.

Olivier Mignen (O)

Université de Brest, INSERM, EFS, UMR 1078, GGB, F-29200 Brest, France Mburgoslozano@sescam.jccm.es olivier.mignen@univ-brest.fr.
UMR1227, Lymphocytes B et Autoimmunité, Université de Brest, INSERM, CHU de Brest, BP824, F29609 Brest, France.
ORCID: 0000-0001-7913-6119

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › The p.E152K-STIM1 mutation deregulates Ca
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Systèmes de seconds messagers › Signalisation calcique › The p.E152K-STIM1 mutation deregulates Ca
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Réticulum endoplasmique › The p.E152K-STIM1 mutation deregulates Ca
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › The p.E152K-STIM1 mutation deregulates Ca
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The p.E152K-STIM1 mutation deregulates Ca
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › The p.E152K-STIM1 mutation deregulates Ca
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › The p.E152K-STIM1 mutation deregulates Ca
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Canaux calciques activés par la libération de calcium › Protéine ORAI1 › The p.E152K-STIM1 mutation deregulates Ca
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Pancréatite chronique › The p.E152K-STIM1 mutation deregulates Ca
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Molécules d'interaction stromale › Molécule-1 d'interaction stromale › The p.E152K-STIM1 mutation deregulates Ca