Structure and assembly of the diiron cofactor in the heme-oxygenase-like domain of the
Catalysis
/ drug effects
Crystallography, X-Ray
Heme Oxygenase (Decyclizing)
/ chemistry
Humans
Ligands
Nitrosourea Compounds
/ toxicity
Nonheme Iron Proteins
/ chemistry
Oxidation-Reduction
Oxygen
/ chemistry
Oxygenases
/ chemistry
Pancreatic Neoplasms
/ chemically induced
Protein Conformation
/ drug effects
Protein Domains
/ genetics
Streptozocin
/ chemistry
N-oxygenase
X-ray crystallography
bioinformatics
streptozotocin
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
26 01 2021
26 01 2021
Historique:
entrez:
20
1
2021
pubmed:
21
1
2021
medline:
12
6
2021
Statut:
ppublish
Résumé
In biosynthesis of the pancreatic cancer drug streptozotocin, the tridomain nonheme-iron oxygenase SznF hydroxylates
Identifiants
pubmed: 33468680
pii: 2015931118
doi: 10.1073/pnas.2015931118
pmc: PMC7848743
pii:
doi:
Substances chimiques
Ligands
0
Nitrosourea Compounds
0
Nonheme Iron Proteins
0
Streptozocin
5W494URQ81
Oxygenases
EC 1.13.-
Heme Oxygenase (Decyclizing)
EC 1.14.14.18
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM132564
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM138580
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM119707
Pays : United States
Organisme : NIH HHS
ID : S10 OD012289
Pays : United States
Informations de copyright
Copyright © 2021 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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