Detection of antibodies to duck tembusu virus in human population with or without the history of contact with ducks.
Serological surveillance
Thai duck farm workers
Thai population
duck tembusu virus
Journal
Transboundary and emerging diseases
ISSN: 1865-1682
Titre abrégé: Transbound Emerg Dis
Pays: Germany
ID NLM: 101319538
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
revised:
25
12
2020
received:
29
06
2020
accepted:
18
01
2021
pubmed:
21
1
2021
medline:
1
4
2022
entrez:
20
1
2021
Statut:
ppublish
Résumé
Duck tembusu virus (DTMUV) is an emerging duck pathogen in China and other Asian countries. It is unclear whether this emerging zoonotic infection poses a threat to humans. A previous study in 2012 showed surprisingly high rates of seropositivity and positive viral detection by RT-PCR in duck farm workers in China. To understand the nature of the threat of this emerging virus, we studied the neutralizing antibody response to a local isolate of DTMUV in an at-risk population, who were workers in duck farms and residents around farming areas in Central Thailand where DTMUV had been previously detected, and in a not-at-risk population, who were people living in the same or neighbouring province, but at a distance from the farms and who had no contact with ducks. The sera from the at-risk population showed higher anti-DTMUV neutralizing antibody titres as compared with those of the not-at-risk population. However, within the at-risk population, workers with direct contact with ducks did not show higher neutralizing titres than those without direct contact. Interestingly, some people in the not-at-risk group also displayed high neutralizing antibody titres to DTMUV. These sera were tested against other endemic Flaviviruses and showed no or low cross-reactivity suggesting the specificity of the neutralizing activity against DTMUV. These data raise a possibility of DTMUV as a potential zoonotic pathogen but the mode of transmission of the virus from ducks or other possible hosts to humans should be explored further.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
870-873Subventions
Organisme : Thailand Research Fund
ID : IRN60W0002
Informations de copyright
© 2021 Wiley-VCH GmbH.
Références
Cao, Z., Zhang, C., Liu, Y., Ye, W., Han, J., Ma, G., … Zhang, D. (2011). Tembusu virus in ducks, China. Emerging Infectious Diseases, 17(10), 1873-1875. https://doi.org/10.3201/eid1710.101890
Chakritbudsabong, W., Taowan, J., Lertwatcharasarakul, P., Phattanakunanan, S., Munkhong, A., Songserm, T., & Chaichoun, K. (2015). Genomic characterization of a new tembusu flavivirus from domestic ducks in Thailand. Thai Journal of Veterinary Medicine, 45(3), 419-425.
Henchal, E., Gentry, M., McCown, J., & Brandt, W. (1982). Dengue virus-specific and flavivirus group determinants identified with monoclonal antibodies by indirect immunofluorescence. American Journal of Tropical Medicine and Hygiene, 31(4), 830-836. https://doi.org/10.4269/ajtmh.1982.31.830
Li, S., Li, X., Zhang, L., Wang, Y., Yu, X., Tian, K., Su, W., Han, B. O., … Su, J. (2013). Duck tembusu virus exhibits neurovirulence in BALB/c mice. Virology Journal, 10, 260. https://doi.org/10.1186/1743-422X-10-260
Li, X., Shi, Y., Liu, Q., Wang, Y., Li, G., Teng, Q., … Li, Z. (2015). Airborne transmission of a novel tembusu virus in ducks. Journal of Clinical Microbiology, 53(8), 2734-2736. https://doi.org/10.1128/JCM.00770-15
Ninvilai, P., Nonthabenjawan, N., Limcharoen, B., Tunterak, W., Oraveerakul, K., Banlunara, W., … Thontiravong, A. (2018). The presence of duck tembusu virus in Thailand since 2007: A retrospective study. Transboundary and Emerging Diseases, 65(5), 1208-1216. https://doi.org/10.1111/tbed.12859
Ninvilai, P., Tunterak, W., Oraveerakul, K., Amonsin, A., & Thontiravong, A. (2019). Genetic characterization of duck tembusu virus in Thailand, 2015-2017: Identification of a novel cluster. Transboundary and Emerging Diseases, 66(5), 1982-1992. https://doi.org/10.1111/tbed.13230
Pandey, B. D., Karabatsos, N., Cropp, B., Tagaki, M., Tsuda, Y., Ichinose, A., & Igarashi, A. (1999). Identification of a flavivirus isolated from mosquitoes in Chiang Mai Thailand. Southeast Asian Journal of Tropical Medicine and Public Health, 30(1), 161-165.
Platt, G. S., Way, H. J., Bowen, E. T. W., Simpson, D. I. H., Hill, M. N., Kamath, S., … Heathcote, O. H. U. (1975). Arbovirus infections in Sarawak, October 1968-February 1970 Tembusu and Sindbis virus isolations from mosquitoes. Annals of Tropical Medicine and Parasitology, 69(1), 65-71. https://doi.org/10.1080/00034983.1975.11686984
Su, J., Li, S., Hu, X., Yu, X., Wang, Y., Liu, P., … Gao, G. F. (2011). Duck egg-drop syndrome caused by BYD virus, a new Tembusu-related flavivirus. PLoS One, 6(3), e18106. https://doi.org/10.1371/journal.pone.0018106
Tang, Y., Diao, Y., Chen, H., Ou, Q., Lui, X., Gao, X., … Wang, L. (2013). Isolation and genetic characterization of Tembusu virus isolated from mosquitoes in Shandong. China. Transboundary and Emerging Diseases, 60(2), 209-216.
Tang, Y., Diao, Y., Yu, C., Gao, X., Ju, X., Xue, C., Lui, X., … Zhang, D. (2013). Characterization of Tembusu virus isolated from naturally infected house sparrows (Passer domesticus) in Northern China. Transboundary and Emerging Diseases, 60(2), 152-158.
Tang, Y., Gao, X., Diao, Y., Feng, Q., Chen, H., Liu, X., Ge, P., … Yu, C. (2013). Tembusu virus in human, China. Transboundary and Emerging Diseases, 60(3), 193-196. https://doi.org/10.1111/tbed.12085
Thontiravong, A., Ninvilai, P., Tunterak, W., Nonthabenjawan, N., Chaiyavong, S., Angkabkingkaew, K., … Amonsin, A. (2015). Tembusu-related flavivirus in ducks, Thailand. Emerging Infectious Diseases, 21(12), 2164-2167. https://doi.org/10.3201/eid2112.150600
Ti, J., Zhang, M., Li, Z., Li, X., & Diao, Y. (2016). Duck tembusu virus exhibits pathogenicity to kunming mice by intracerebral inoculation. Frontiers in Microbiology, 7, 190. https://doi.org/10.3389/fmicb.2016.00190
Wang, H.-J., Li, X.-F., Liu, L., Xu, Y.-P., Ye, Q., Deng, Y.-Q., … Qin, C.-F. (2016). The emerging duck flavivirus is not pathogenic for primates and is highly sensitive to mammalian interferon antiviral signaling. Journal of Virology, 90(14), 6538-6548. https://doi.org/10.1128/JVI.00197-16
Yu, G., Lin, Y., Tang, Y., & Diao, Y. (2018). Evolution of tembusu virus in ducks, chickens, geese, sparrows, and mosquitoes in Northern China. Viruses, 10(9), 485. https://doi.org/10.3390/v10090485
Zhang, Y., Li, X., Chen, H., Ti, J., Yang, G., Zhang, L. U., … Diao, Y. (2015). Evidence of possible vertical transmission of Tembusu virus in ducks. Veterinary Microbiology, 179(3-4), 149-154. https://doi.org/10.1016/j.vetmic.2015.06.004