Guanylyl cyclase C as a biomarker for immunotherapies for the treatment of gastrointestinal malignancies.
GUCY2C
biomarker
colorectal cancer
gastrointestinal cancer
immunotherapy
Journal
Biomarkers in medicine
ISSN: 1752-0371
Titre abrégé: Biomark Med
Pays: England
ID NLM: 101312535
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
pubmed:
21
1
2021
medline:
15
12
2021
entrez:
20
1
2021
Statut:
ppublish
Résumé
Gastrointestinal cancers encompass a diverse class of tumors arising in the GI tract, including esophagus, stomach, pancreas and colorectum. Collectively, gastrointestinal cancers compose a high fraction of all cancer deaths, highlighting an unmet need for novel and effective therapies. In this context, the transmembrane receptor guanylyl cyclase C (GUCY2C) has emerged as an attractive target for the prevention, detection and treatment of many gastrointestinal tumors. GUCY2C is an intestinally-restricted protein implicated in tumorigenesis that is universally expressed by primary and metastatic colorectal tumors as well as ectopically expressed by esophageal, gastric and pancreatic cancers. This review summarizes the current state of GUCY2C-targeted modalities in the management of gastrointestinal malignancies, with special focus on colorectal cancer, the most incident gastrointestinal malignancy.
Identifiants
pubmed: 33470843
doi: 10.2217/bmm-2020-0359
pmc: PMC8293028
doi:
Substances chimiques
Biomarkers
0
GUCY2C protein, human
EC 4.6.1.2
Receptors, Enterotoxin
EC 4.6.1.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
201-217Subventions
Organisme : NCI NIH HHS
ID : F31 CA225123
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA204481
Pays : United States
Organisme : NCI NIH HHS
ID : F30 CA232469
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA206026
Pays : United States
Organisme : NIDDK NIH HHS
ID : F30 DK127639
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA056036
Pays : United States
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