Trophectoderm mechanics direct epiblast shape upon embryo implantation.
epiblast
morphogenesis
mouse/human implantation
tissue remodeling
trophectoderm
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
19 01 2021
19 01 2021
Historique:
received:
08
05
2020
revised:
12
10
2020
accepted:
22
12
2020
entrez:
20
1
2021
pubmed:
21
1
2021
medline:
29
1
2022
Statut:
ppublish
Résumé
Implantation is a hallmark of mammalian embryogenesis during which embryos establish their contacts with the maternal endometrium, remodel, and undertake growth and differentiation. The mechanisms and sequence of events through which embryos change their shape during this transition are largely unexplored. Here, we show that the first extraembryonic lineage, the polar trophectoderm, is the key regulator for remodeling the embryonic epiblast. Loss of its function after immuno-surgery or inhibitor treatments prevents the epiblast shape transitions. In the mouse, the polar trophectoderm exerts physical force upon the epiblast, causing it to transform from an oval into a cup shape. In human embryos, the polar trophectoderm behaves in the opposite manner, exerting a stretching force. By mimicking this stretching behavior in mouse embryogenesis, we could direct the epiblast to adopt the disc-like shape characteristic of human embryos at this stage. Thus, the polar trophectoderm acts as a conserved regulator of epiblast shape.
Identifiants
pubmed: 33472064
pii: S2211-1247(20)31644-2
doi: 10.1016/j.celrep.2020.108655
pmc: PMC7816124
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108655Subventions
Organisme : NICHD NIH HHS
ID : DP1 HD104575
Pays : United States
Organisme : Wellcome Trust
ID : 207415/Z/17/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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