Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain.

Action Potentials / genetics Animals Axons / metabolism Brain / physiopathology Mice
action potential computational modeling conduction velocity myelin node of Ranvier oligodendrocyte periaxonal space plasticity spatial learning transcranial magnetic stimulation

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
19 01 2021
Historique:
received: 22 05 2020
revised: 18 11 2020
accepted: 21 12 2020
entrez: 20 1 2021
pubmed: 21 1 2021
medline: 29 1 2022
Statut: ppublish

Résumé

Central nervous system myelination increases action potential conduction velocity. However, it is unclear how myelination is coordinated to ensure the temporally precise arrival of action potentials and facilitate information processing within cortical and associative circuits. Here, we show that myelin sheaths, supported by mature oligodendrocytes, remain plastic in the adult mouse brain and undergo subtle structural modifications to influence action potential conduction velocity. Repetitive transcranial magnetic stimulation and spatial learning, two stimuli that modify neuronal activity, alter the length of the nodes of Ranvier and the size of the periaxonal space within active brain regions. This change in the axon-glial configuration is independent of oligodendrogenesis and robustly alters action potential conduction velocity. Because aptitude in the spatial learning task was found to correlate with action potential conduction velocity in the fimbria-fornix pathway, modifying the axon-glial configuration may be a mechanism that facilitates learning in the adult mouse brain.

Identifiants

DOI: 10.1016/j.celrep.2020.108641 PMID: 33472075
pubmed: 33472075
pii: S2211-1247(20)31630-2
doi: 10.1016/j.celrep.2020.108641
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108641

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Carlie L Cullen (CL)

Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.

Renee E Pepper (RE)

Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.

Mackenzie T Clutterbuck (MT)

Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.

Kimberley A Pitman (KA)

Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.

Viola Oorschot (V)

Ramaciotti Centre for Cryo-Electron Microscopy, Monash University, Melbourne, VIC 3800, Australia.

Loic Auderset (L)

Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.

Alexander D Tang (AD)

Experimental and Regenerative Neuroscience, School of Biological Sciences, University of Western Australia, Perth, WA 6009, Australia.

Georg Ramm (G)

Ramaciotti Centre for Cryo-Electron Microscopy, Monash University, Melbourne, VIC 3800, Australia.

Ben Emery (B)

Jungers Center for Neurosciences Research, Department of Neurology, Oregon Health and Science University, Portland, OR 97239-3098, USA.

Jennifer Rodger (J)

Experimental and Regenerative Neuroscience, School of Biological Sciences, University of Western Australia, Perth, WA 6009, Australia; Perron Institute for Neurological and Translational Research, Perth, WA 6009, Australia.

Renaud B Jolivet (RB)

Département de Physique Nucléaire et Corpusculaire, University of Geneva, 1211 Geneva 4, Switzerland.

Kaylene M Young (KM)

Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia. Electronic address: kaylene.young@utas.edu.au.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Potentiels de membrane › Potentiels d'action › Periaxonal and nodal plasticities modulate...
questionsmedicales.fr › Eucaryotes › Animaux › Periaxonal and nodal plasticities modulate...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Axones › Periaxonal and nodal plasticities modulate...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Periaxonal and nodal plasticities modulate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Periaxonal and nodal plasticities modulate...