Differential gene expression in cisplatin-resistant and -sensitive testicular germ cell tumor cell lines.
cisplatin
gene expression array
pluripotency factors
prognostic biomarkers
testicular germ cell tumors
Journal
Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965
Informations de publication
Date de publication:
22 Dec 2020
22 Dec 2020
Historique:
received:
02
11
2020
accepted:
30
11
2020
entrez:
21
1
2021
pubmed:
22
1
2021
medline:
22
1
2021
Statut:
epublish
Résumé
Testicular germ cell tumors (TGCTs) represent a well curable malignity due to their exceptional response to cisplatin (CDDP). Despite remarkable treatment results, approximately 5% of TGCT patients develop CDDP resistance and die. Exceptional curability makes TGCTs a highly valuable model system for studying the molecular mechanisms of CDDP sensitivity. Our study was aimed at revealing difference in gene expression between the CDDP-resistant and -sensitive TGCT cell lines, and hence at identifying candidate genes that could serve as potential biomarkers of CDDP response. Using gene expression array, we identified 281 genes that are differentially expressed in CDDP-resistant compared to -sensitive TGCT cell lines. The expression of 25 genes with the highest fold change was validated by RT-qPCR. Of them,
Identifiants
pubmed: 33473258
doi: 10.18632/oncotarget.27844
pii: 27844
pmc: PMC7771712
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4735-4753Informations de copyright
Copyright: © 2020 Roška et al.
Déclaration de conflit d'intérêts
CONFLICTS OF INTEREST Authors have no conflicts of interest to declare.
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