[A Review of the State of Purinergic Signaling and Psychological Stress].

ATP Adenosine Psychological stress Purinergic receptor Purinergic signaling

Journal

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
ISSN: 1672-173X
Titre abrégé: Sichuan Da Xue Xue Bao Yi Xue Ban
Pays: China
ID NLM: 101162609

Informations de publication

Date de publication:
Jan 2021
Historique:
entrez: 21 1 2021
pubmed: 22 1 2021
medline: 23 1 2021
Statut: ppublish

Résumé

Purinergic signaling is involved in multiple physiological and pathological processes. Psychological stress, as an inharmonious state in response to stressors, is closely related to the function or dysfunction of purinergic signaling. Abnormal expression of ATP interceptors caused by stress leads to psychological stress-related diseases, such as anxiety, depression, post-traumatic stress disorder and schizophrenia. Recent studies demonstrate that a complex network of purinergic signaling (such as ATP, adenosine and P2X2R, P2X3R, P2X4R, P2X7R, A1R, A2AR) plays a key role in psychological stress, but the specific mechanism remains to be further studied. And few studies focus on the application of ATP real-time detecting to psychological stress animal models, so the specific biological role of ATP in the process of stress is still unknown. This review will summarize the relationship between purinergic signaling and psychological stress and propose to apply the duplicate ATP real-time detection technology and purinergic compounds on psychological stress research in order to provide novel potential targets for the treatment of stress-related diseases.

Identifiants

pubmed: 33474886
doi: 10.12182/20210160102
pmc: PMC10408934
doi:

Types de publication

Journal Article Review

Langues

chi

Sous-ensembles de citation

IM

Pagination

33-38

Informations de copyright

Copyright© by Editorial Board of Journal of Sichuan University (Medical Sciences).

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Auteurs

Wen-Jing Ren (WJ)

Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
Acupuncture and Chronobiology Key Laboratory of Sichuan Province, Chengdu 610075, China.

Yong Tang (Y)

Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
Acupuncture and Chronobiology Key Laboratory of Sichuan Province, Chengdu 610075, China.

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Classifications MeSH