Epidemiology of cytomegalovirus Infection among mothers and infants in Colombia.
Adult
Antibodies, Viral
/ blood
Child, Preschool
Colombia
/ epidemiology
Cytomegalovirus
/ genetics
Cytomegalovirus Infections
/ congenital
DNA, Viral
/ urine
Female
Gestational Age
Humans
Immunoglobulin G
/ blood
Infant
Mothers
Pregnancy
Pregnancy Complications, Infectious
/ epidemiology
Saliva
/ virology
Seroepidemiologic Studies
CMV
Colombia
congenital infection
cytomegalovirus
newborns
postnatal infection
prevalence
seroprevalence
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
revised:
07
01
2021
received:
18
11
2020
accepted:
19
01
2021
pubmed:
22
1
2021
medline:
30
12
2021
entrez:
21
1
2021
Statut:
ppublish
Résumé
We assessed maternal and infant cytomegalovirus (CMV) infection in Colombia. Maternal serum was tested for CMV immunoglobulin G antibodies at a median of 10 (interquartile range: 8-12) weeks gestation (n = 1501). CMV DNA polymerase chain reaction was performed on infant urine to diagnose congenital (≤21 days of life) and postnatal (>21 days) infection. Maternal CMV seroprevalence was 98.1% (95% confidence interval [CI]: 97.5%-98.8%). Congenital CMV prevalence was 8.4 (95% CI: 3.9%-18.3%; 6/711) per 1000 live births. Among 472 infants without confirmed congenital CMV infection subsequently tested at age 6 months, 258 (54.7%, 95% CI: 50.2%-59.1%) had postnatal infection.
Identifiants
pubmed: 33475162
doi: 10.1002/jmv.26815
pmc: PMC8292416
mid: NIHMS1682554
doi:
Substances chimiques
Antibodies, Viral
0
DNA, Viral
0
Immunoglobulin G
0
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
6393-6397Subventions
Organisme : Intramural CDC HHS
ID : CC999999
Pays : United States
Informations de copyright
© 2021 Wiley Periodicals LLC.
Références
Pediatrics. 2013 Jun;131(6):e1937-45
pubmed: 23713111
Am J Public Health. 2017 Apr;107(4):525-531
pubmed: 28207337
JAMA. 2010 Apr 14;303(14):1375-82
pubmed: 20388893
J Infect Dis. 2020 Mar 5;221(Suppl 1):S86-S93
pubmed: 32134475
Lancet Infect Dis. 2017 Jun;17(6):e177-e188
pubmed: 28291720
Int J Infect Dis. 2014 May;22:44-8
pubmed: 24631522
Epidemiol Health. 2020;42:e2020060
pubmed: 32882120
Clin Infect Dis. 2017 Aug 01;65(3):398-404
pubmed: 28419213
Pediatr Infect Dis J. 2018 Jul;37(7):627-631
pubmed: 29889809