Post-lockdown abatement of COVID-19 by fast periodic switching.
Journal
PLoS computational biology
ISSN: 1553-7358
Titre abrégé: PLoS Comput Biol
Pays: United States
ID NLM: 101238922
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
27
07
2020
accepted:
03
12
2020
revised:
04
02
2021
pubmed:
22
1
2021
medline:
20
2
2021
entrez:
21
1
2021
Statut:
epublish
Résumé
COVID-19 abatement strategies have risks and uncertainties which could lead to repeating waves of infection. We show-as proof of concept grounded on rigorous mathematical evidence-that periodic, high-frequency alternation of into, and out-of, lockdown effectively mitigates second-wave effects, while allowing continued, albeit reduced, economic activity. Periodicity confers (i) predictability, which is essential for economic sustainability, and (ii) robustness, since lockdown periods are not activated by uncertain measurements over short time scales. In turn-while not eliminating the virus-this fast switching policy is sustainable over time, and it mitigates the infection until a vaccine or treatment becomes available, while alleviating the social costs associated with long lockdowns. Typically, the policy might be in the form of 1-day of work followed by 6-days of lockdown every week (or perhaps 2 days working, 5 days off) and it can be modified at a slow-rate based on measurements filtered over longer time scales. Our results highlight the potential efficacy of high frequency switching interventions in post lockdown mitigation. All code is available on Github at https://github.com/V4p1d/FPSP_Covid19. A software tool has also been developed so that interested parties can explore the proof-of-concept system.
Identifiants
pubmed: 33476332
doi: 10.1371/journal.pcbi.1008604
pii: PCOMPBIOL-D-20-01341
pmc: PMC7861565
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1008604Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Nat Commun. 2020 Oct 9;11(1):5106
pubmed: 33037190
Proc Biol Sci. 2006 Oct 7;273(1600):2541-50
pubmed: 16959647
Nature. 2020 Aug;584(7820):257-261
pubmed: 32512579
Nat Med. 2020 Jun;26(6):855-860
pubmed: 32322102
Lancet Public Health. 2020 Jul;5(7):e375-e385
pubmed: 32502389
Sci Total Environ. 2020 Jul 10;725:138539
pubmed: 32304973
Proc Natl Acad Sci U S A. 2020 May 12;117(19):10484-10491
pubmed: 32327608
J Travel Med. 2020 May 18;27(3):
pubmed: 32181488
J R Soc Interface. 2019 Jul 26;16(156):20190202
pubmed: 31362618
Nature. 2007 Mar 29;446(7135):533-6
pubmed: 17392785
PLoS One. 2020 Aug 6;15(8):e0236857
pubmed: 32760081
Math Biosci Eng. 2006 Jan;3(1):161-72
pubmed: 20361816
BMC Med. 2020 May 7;18(1):124
pubmed: 32375776
Science. 2020 May 22;368(6493):860-868
pubmed: 32291278
Lancet. 2020 May 23;395(10237):1595-1598
pubmed: 32380041