Functions of nuclear receptors SUMOylation.

Humans Protein Processing, Post-Translational Receptors, Cytoplasmic and Nuclear Sumoylation Transcription Factors / metabolism Ubiquitination
Crosstalk Nuclear receptors SUMO SUMOylation

Journal

Clinica chimica acta; international journal of clinical chemistry
ISSN: 1873-3492
Titre abrégé: Clin Chim Acta
Pays: Netherlands
ID NLM: 1302422

Informations de publication

Date de publication:
May 2021
Historique:
received: 16 10 2020
revised: 13 01 2021
accepted: 14 01 2021
pubmed: 22 1 2021
medline: 22 6 2021
entrez: 21 1 2021
Statut: ppublish

Résumé

The nuclear receptor superfamily is a family of ligand-activated transcription factors that play a key role in cell metabolism and human diseases. They can be modified after translation, such as acetylation, ubiquitination, phosphorylation and SUMOylation. Crosstalk between SUMO and ubiquitin, phosphorylation and acetylation regulates a variety of metabolic and physiological activities. Nuclear receptors play an important role in lipid metabolism, inflammation, bile acid homeostasis and autophagy. SUMOylation nuclear receptors can regulate their function and affect cell metabolism. It also provides a potential therapeutic target for atherosclerosis, tumor and other metabolic and inflammation-related diseases. This review focuses on the function of SUMOylation nuclear receptors.

Identifiants

DOI: 10.1016/j.cca.2021.01.007 PMID: 33476589
pubmed: 33476589
pii: S0009-8981(21)00016-4
doi: 10.1016/j.cca.2021.01.007
pii:
doi:

Substances chimiques

Receptors, Cytoplasmic and Nuclear 0
Transcription Factors 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

27-33

Informations de copyright

Copyright © 2021. Published by Elsevier B.V.

Auteurs

Wenhui Liu (W)

Department of Gastroenterology, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China; Liver Disease Laboratory, Clinical Research Institute, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China.

Min Zeng (M)

Department of Gastroenterology, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China; Liver Disease Laboratory, Clinical Research Institute, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China.

Nian Fu (N)

Department of Gastroenterology, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China; Liver Disease Laboratory, Clinical Research Institute, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China. Electronic address: 2002funian@163.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Functions of nuclear receptors SUMOylation.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Functions of nuclear receptors SUMOylation.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Functions of nuclear receptors SUMOylation.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Ubiquitination › Sumoylation › Functions of nuclear receptors SUMOylation.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Functions of nuclear receptors SUMOylation.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Ubiquitination › Functions of nuclear receptors SUMOylation.