Association of Serum Triglyceride Levels with Severity in Acute Pancreatitis: Results from an International, Multicenter Cohort Study.
Acute pancreatitis
Hypertriglyceridemia
Pancreatitis
Severity
Triglycerides
Journal
Digestion
ISSN: 1421-9867
Titre abrégé: Digestion
Pays: Switzerland
ID NLM: 0150472
Informations de publication
Date de publication:
2021
2021
Historique:
received:
28
04
2020
accepted:
30
10
2020
pubmed:
22
1
2021
medline:
4
9
2021
entrez:
21
1
2021
Statut:
ppublish
Résumé
Hypertriglyceridemia (HTG) is considered within the top 5 etiologies in acute pancreatitis (AP), but the association of serum triglyceride (TG) levels with the clinical course of AP remains controversial. This study aims to examine the effect of TG levels on severity of AP. Patients were enrolled prospectively through APPRENTICE. High TG levels were defined based on the Endocrine Society Clinical Practice Guidelines. HTG was categorized as mild (serum TG levels 150-199 mg/dL), moderate (200-999 mg/dL), severe (1,000-1,999 mg/dL), and very severe (≥2,000 mg/dL). Severity of AP was based on the revised Atlanta classification criteria. Early TG levels were measured in 764 subjects and found elevated in 342 (120 with mild; 176, moderate; and 46, severe/very severe HTG). Patients with increased TG levels were younger (age ≥60, 16.7 vs. 30.3%), more likely to be male (66.1 vs. 51.2%), with more frequent alcohol use (62.8 vs. 50.7%), and diabetes mellitus (30.2 vs. 12.3%; all p ≤ 0.005). Severe AP (24.9 vs. 10.0%), ICU admission (32.5 vs. 19.7%), and mortality (5.3 vs. 1.7%; all p ≤ 0.005) were more frequently seen in patients with elevated TG levels. Based on multivariable analysis, elevated TG levels were independently associated with severe AP (p < 0.05). This large multicenter study confirms that elevated TG levels are associated with severe disease regardless of AP etiology.
Sections du résumé
BACKGROUND
BACKGROUND
Hypertriglyceridemia (HTG) is considered within the top 5 etiologies in acute pancreatitis (AP), but the association of serum triglyceride (TG) levels with the clinical course of AP remains controversial.
OBJECTIVES
OBJECTIVE
This study aims to examine the effect of TG levels on severity of AP.
METHODS
METHODS
Patients were enrolled prospectively through APPRENTICE. High TG levels were defined based on the Endocrine Society Clinical Practice Guidelines. HTG was categorized as mild (serum TG levels 150-199 mg/dL), moderate (200-999 mg/dL), severe (1,000-1,999 mg/dL), and very severe (≥2,000 mg/dL). Severity of AP was based on the revised Atlanta classification criteria.
RESULTS
RESULTS
Early TG levels were measured in 764 subjects and found elevated in 342 (120 with mild; 176, moderate; and 46, severe/very severe HTG). Patients with increased TG levels were younger (age ≥60, 16.7 vs. 30.3%), more likely to be male (66.1 vs. 51.2%), with more frequent alcohol use (62.8 vs. 50.7%), and diabetes mellitus (30.2 vs. 12.3%; all p ≤ 0.005). Severe AP (24.9 vs. 10.0%), ICU admission (32.5 vs. 19.7%), and mortality (5.3 vs. 1.7%; all p ≤ 0.005) were more frequently seen in patients with elevated TG levels. Based on multivariable analysis, elevated TG levels were independently associated with severe AP (p < 0.05).
CONCLUSION
CONCLUSIONS
This large multicenter study confirms that elevated TG levels are associated with severe disease regardless of AP etiology.
Identifiants
pubmed: 33477149
pii: 000512682
doi: 10.1159/000512682
pmc: PMC9191264
mid: NIHMS1811301
doi:
Substances chimiques
Triglycerides
0
Types de publication
Multicenter Study
News
Langues
eng
Sous-ensembles de citation
IM
Pagination
809-813Subventions
Organisme : NCI NIH HHS
ID : T32 CA186873
Pays : United States
Informations de copyright
© 2021 S. Karger AG, Basel.
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