Myeloid-derived suppressor cells and their association with vaccine immunogenicity in South African infants.
Antibodies, Bacterial
/ blood
BCG Vaccine
/ immunology
Cohort Studies
Diphtheria-Tetanus-Pertussis Vaccine
/ immunology
Female
Hepatitis B Vaccines
/ immunology
Humans
Immunogenicity, Vaccine
/ immunology
Infant
Infant, Newborn
Male
Myeloid-Derived Suppressor Cells
/ immunology
Prospective Studies
South Africa
MDSC
cellular immunity
infant immunity
vaccines
Journal
Journal of leukocyte biology
ISSN: 1938-3673
Titre abrégé: J Leukoc Biol
Pays: England
ID NLM: 8405628
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
revised:
23
11
2020
received:
26
05
2020
accepted:
28
12
2020
pubmed:
22
1
2021
medline:
6
11
2021
entrez:
21
1
2021
Statut:
ppublish
Résumé
The role of Myeloid-Derived Suppressor Cells (MDSC) in infant immune ontogeny is unknown. Here, we evaluated MDSC frequency and relationship with infant vaccine responses throughout the first year of life in a prospective cohort study. Ninety-one South African infant-mother pairs were enrolled at delivery, and blood samples were collected at 0, 6, 10, and 14 weeks, 6 months, 9 months, and 1 year. MDSC frequencies were quantified, and immune responses to the childhood vaccines Bacillus Calmette-Guérin (BCG), hepatitis B (HepB), and combination diphtheria, tetanus, and pertussis (dTaP) were measured by Ag-specific CD4
Identifiants
pubmed: 33477200
doi: 10.1002/JLB.5A0420-281R
pmc: PMC8292449
mid: NIHMS1661581
doi:
Substances chimiques
Antibodies, Bacterial
0
BCG Vaccine
0
Diphtheria-Tetanus-Pertussis Vaccine
0
Hepatitis B Vaccines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
939-950Subventions
Organisme : NICHD NIH HHS
ID : K08 HD069201
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI027757
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI100018
Pays : United States
Informations de copyright
©2021 Society for Leukocyte Biology.
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