Utility of 1,3 β-d-Glucan Assay for Guidance in Antifungal Stewardship Programs for Oncologic Patients and Solid Organ Transplant Recipients.
1,3 β-d-glucan
antifungal stewardship
antifungals
biomarkers
invasive fungal infections
oncologic patients
solid organ transplant
Journal
Journal of fungi (Basel, Switzerland)
ISSN: 2309-608X
Titre abrégé: J Fungi (Basel)
Pays: Switzerland
ID NLM: 101671827
Informations de publication
Date de publication:
17 Jan 2021
17 Jan 2021
Historique:
received:
30
11
2020
revised:
25
12
2020
accepted:
11
01
2021
entrez:
22
1
2021
pubmed:
23
1
2021
medline:
23
1
2021
Statut:
epublish
Résumé
The implementation of 1,3 β-d-glucan (BDG) has been proposed as a diagnostic tool in antifungal stewardship programs (ASPs). We aimed to analyze the influence of serum BDG in an ASP for oncologic patients and solid organ transplant (SOT) recipients. We conducted a pre-post study. In the initial period (PRE), the ASP was based on bedside advice, and this was complemented with BDG in the post-period (POST). Performance parameters of the BDG assay were determined. Antifungal (AF) use adequacy was evaluated using a point score. Clinical outcomes and AF costs were also compared before and after the intervention. Overall, 85 patients were included in the PRE-period and 112 in the POST-period. Probable or proven fungal infections were similar in both groups (54.1% vs. 57.1%;
Identifiants
pubmed: 33477250
pii: jof7010059
doi: 10.3390/jof7010059
pmc: PMC7830184
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Instituto de Salud Carlos III Madrid Spain. European Regional Development Fund (FEDER) "A way of making Europe"
ID : PI13/01148
Organisme : Fundación Mutua Madrileña
ID : No Grant Numer
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