Insights into the Role of Tick Salivary Protease Inhibitors during Ectoparasite-Host Crosstalk.
drug discovery
protease inhibitors
proteases
tick saliva
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Jan 2021
17 Jan 2021
Historique:
received:
25
12
2020
revised:
12
01
2021
accepted:
13
01
2021
entrez:
22
1
2021
pubmed:
23
1
2021
medline:
23
4
2021
Statut:
epublish
Résumé
Protease inhibitors (PIs) are ubiquitous regulatory proteins present in all kingdoms. They play crucial tasks in controlling biological processes directed by proteases which, if not tightly regulated, can damage the host organism. PIs can be classified according to their targeted proteases or their mechanism of action. The functions of many PIs have now been characterized and are showing clinical relevance for the treatment of human diseases such as arthritis, hepatitis, cancer, AIDS, and cardiovascular diseases, amongst others. Other PIs have potential use in agriculture as insecticides, anti-fungal, and antibacterial agents. PIs from tick salivary glands are special due to their pharmacological properties and their high specificity, selectivity, and affinity to their target proteases at the tick-host interface. In this review, we discuss the structure and function of PIs in general and those PI superfamilies abundant in tick salivary glands to illustrate their possible practical applications. In doing so, we describe tick salivary PIs that are showing promise as drug candidates, highlighting the most promising ones tested in vivo and which are now progressing to preclinical and clinical trials.
Identifiants
pubmed: 33477394
pii: ijms22020892
doi: 10.3390/ijms22020892
pmc: PMC7831016
pii:
doi:
Substances chimiques
Protease Inhibitors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Grantová Agentura České Republiky
ID : 19-382 07247S
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