Brain Metastases in Elderly Patients-The Role of Surgery in the Context of Systemic Treatment.

Brain metastases elderly patients survival targeted therapy

Journal

Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646

Informations de publication

Date de publication:
18 Jan 2021
Historique:
received: 03 12 2020
revised: 25 12 2020
accepted: 11 01 2021
entrez: 22 1 2021
pubmed: 23 1 2021
medline: 23 1 2021
Statut: epublish

Résumé

In patients with brain metastases (BM), advanced age is considered a negative prognostic factor. To address the potential reasons for that, we assessed 807 patients who had undergone BM resection; 315 patients aged at least 65 years (group A) were compared with 492 younger patients (group B). We analyzed the impact of the pre- and postoperative Karnofsky performance status (KPS), postoperative treatment structure and post-treatment survival. BM resection significantly improved KPS scores in both groups (

Identifiants

pubmed: 33477588
pii: brainsci11010123
doi: 10.3390/brainsci11010123
pmc: PMC7831306
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Martin Proescholdt (M)

Department of Neurosurgery, University Hospital Regensburg, Franz Josef Strauß Allee 11, 93053 Regensburg, Germany.
Wilhelm Sander Neuro-Oncology Unit, University Hospital Regensburg, Franz Josef Strauß Allee 11, 93053 Regensburg, Germany.

Stephanie T Jünger (ST)

Department of General Neurosurgery, University Hospital Cologne, Kerpener Straße 62, 50937 Cologne, Germany.

Petra Schödel (P)

Department of Neurosurgery, University Hospital Regensburg, Franz Josef Strauß Allee 11, 93053 Regensburg, Germany.
Wilhelm Sander Neuro-Oncology Unit, University Hospital Regensburg, Franz Josef Strauß Allee 11, 93053 Regensburg, Germany.

Karl-Michael Schebesch (KM)

Department of Neurosurgery, University Hospital Regensburg, Franz Josef Strauß Allee 11, 93053 Regensburg, Germany.
Wilhelm Sander Neuro-Oncology Unit, University Hospital Regensburg, Franz Josef Strauß Allee 11, 93053 Regensburg, Germany.

Christian Doenitz (C)

Department of Neurosurgery, University Hospital Regensburg, Franz Josef Strauß Allee 11, 93053 Regensburg, Germany.
Wilhelm Sander Neuro-Oncology Unit, University Hospital Regensburg, Franz Josef Strauß Allee 11, 93053 Regensburg, Germany.

Tobias Pukrop (T)

Wilhelm Sander Neuro-Oncology Unit, University Hospital Regensburg, Franz Josef Strauß Allee 11, 93053 Regensburg, Germany.
Department of Oncology, University Hospital Regensburg, Franz Josef Strauß Allee 11, 93053 Regensburg, Germany.

Julius Höhne (J)

Department of Neurosurgery, University Hospital Regensburg, Franz Josef Strauß Allee 11, 93053 Regensburg, Germany.
Wilhelm Sander Neuro-Oncology Unit, University Hospital Regensburg, Franz Josef Strauß Allee 11, 93053 Regensburg, Germany.

Nils-Ole Schmidt (NO)

Department of Neurosurgery, University Hospital Regensburg, Franz Josef Strauß Allee 11, 93053 Regensburg, Germany.
Wilhelm Sander Neuro-Oncology Unit, University Hospital Regensburg, Franz Josef Strauß Allee 11, 93053 Regensburg, Germany.

Martin Kocher (M)

Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Kerpener Straße 62, 50937 Cologne, Germany.

Holger Schulz (H)

PIOH, Clinic for Oncology and Hematology, Kölner Straße 9, 50226 Frechen, Germany.

Maximilian Ruge (M)

Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Kerpener Straße 62, 50937 Cologne, Germany.

Kevin König (K)

Department of General Neurosurgery, University Hospital Cologne, Kerpener Straße 62, 50937 Cologne, Germany.

Roland Goldbrunner (R)

Department of General Neurosurgery, University Hospital Cologne, Kerpener Straße 62, 50937 Cologne, Germany.

Stefan Grau (S)

Department of General Neurosurgery, University Hospital Cologne, Kerpener Straße 62, 50937 Cologne, Germany.

Classifications MeSH