T-Cell Lymphoma Clonality by Copy Number Variation Analysis of T-Cell Receptor Genes.
T-cell lymphoma
T-cell receptor
clonality
copy number variation analysis
whole genome sequencing
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
19 Jan 2021
19 Jan 2021
Historique:
received:
25
12
2020
accepted:
11
01
2021
entrez:
22
1
2021
pubmed:
23
1
2021
medline:
23
1
2021
Statut:
epublish
Résumé
T-cell lymphomas arise from a single neoplastic clone and exhibit identical patterns of deletions in T-cell receptor (TCR) genes. Whole genome sequencing (WGS) data represent a treasure trove of information for the development of novel clinical applications. However, the use of WGS to identify clonal T-cell proliferations has not been systematically studied. In this study, based on WGS data, we identified monoclonal rearrangements (MRs) of T-cell receptors (TCR) genes using a novel segmentation algorithm and copy number computation. We evaluated the feasibility of this technique as a marker of T-cell clonality using T-cell lymphomas (TCL,
Identifiants
pubmed: 33477749
pii: cancers13020340
doi: 10.3390/cancers13020340
pmc: PMC7832336
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Medical Research Council
ID : CSAINV17nov016, WBS R-179-000-063-213
Organisme : National Medical Research Council
ID : SYMPHONY)(NMRC May 2018 / OF-LCG
Organisme : National Medical Research Council
ID : NMRC-OFIRG16NOV090
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