New Prognostic Biomarkers in Metastatic Castration-Resistant Prostate Cancer.
DNA repair defects
PTEN
androgen receptor
prognostic biomarkers
prostate cancer
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
19 01 2021
19 01 2021
Historique:
received:
16
12
2020
revised:
11
01
2021
accepted:
13
01
2021
entrez:
22
1
2021
pubmed:
23
1
2021
medline:
24
6
2021
Statut:
epublish
Résumé
Prostate cancer is one of the most frequent cancers in men and is a common cause of cancer-related death. Despite significant progress in the diagnosis and treatment of this tumor, patients who relapse after radical treatments inevitably develop metastatic disease. Patient stratification is therefore key in this type of cancer, and there is an urgent need for prognostic biomarkers that can define patients' risk of cancer-related death. In the last 10 years, multiple prognostic factors have been identified and studied. Here, we review the literature available and discuss the most common aberrant genomic pathways in metastatic castration-resistant prostate cancer shown to have a prognostic relevance in this setting.
Identifiants
pubmed: 33478015
pii: cells10010193
doi: 10.3390/cells10010193
pmc: PMC7835961
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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