Low serum vitamin D level associated with incident advanced liver disease in the general population - a prospective study.
Advanced liver disease
S-25(OH)D
cirrhosis
vitamin D
Journal
Scandinavian journal of gastroenterology
ISSN: 1502-7708
Titre abrégé: Scand J Gastroenterol
Pays: England
ID NLM: 0060105
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
pubmed:
23
1
2021
medline:
19
8
2021
entrez:
22
1
2021
Statut:
ppublish
Résumé
Vitamin D deficiency is a common finding in chronic liver disease. It has also been linked to the pathogenesis of non-alcoholic fatty liver disease, hepatic fibrogenesis, decompensation and hepatocellular carcinoma. We analyzed whether serum vitamin D is associated with incident advanced liver disease in the general population. Serum 25-hydroxyvitamin D was measured in 13807 individuals participating in the Finnish population-based health examination surveys FINRISK 1997 and Health 2000. Data were linked with incident advanced liver disease (hospitalization, cancer or death related to liver disease). During a follow-up of 201444 person-years 148 severe liver events occurred. Analyses were performed using multivariable Cox regression analyses. Vitamin D level associated with incident advanced liver disease with the hazard ratio of 0.972 (95% confidence interval 0.943-0.976, Low vitamin D level is linked to incident advanced liver disease at population level.
Sections du résumé
BACKGROUND
BACKGROUND
Vitamin D deficiency is a common finding in chronic liver disease. It has also been linked to the pathogenesis of non-alcoholic fatty liver disease, hepatic fibrogenesis, decompensation and hepatocellular carcinoma.
AIMS
OBJECTIVE
We analyzed whether serum vitamin D is associated with incident advanced liver disease in the general population.
METHODS
METHODS
Serum 25-hydroxyvitamin D was measured in 13807 individuals participating in the Finnish population-based health examination surveys FINRISK 1997 and Health 2000. Data were linked with incident advanced liver disease (hospitalization, cancer or death related to liver disease). During a follow-up of 201444 person-years 148 severe liver events occurred. Analyses were performed using multivariable Cox regression analyses.
RESULTS
RESULTS
Vitamin D level associated with incident advanced liver disease with the hazard ratio of 0.972 (95% confidence interval 0.943-0.976,
CONCLUSION
CONCLUSIONS
Low vitamin D level is linked to incident advanced liver disease at population level.
Identifiants
pubmed: 33478287
doi: 10.1080/00365521.2021.1873412
doi:
Substances chimiques
Vitamin D
1406-16-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM