Anti-tumor activity of resveratrol against gastric cancer: a review of recent advances with an emphasis on molecular pathways.
Anti‐tumor activity
Cancer prevention
Cell signaling
Gastric cancer
Molecular pathways
Resveratrol
Journal
Cancer cell international
ISSN: 1475-2867
Titre abrégé: Cancer Cell Int
Pays: England
ID NLM: 101139795
Informations de publication
Date de publication:
21 Jan 2021
21 Jan 2021
Historique:
received:
17
11
2020
accepted:
11
01
2021
entrez:
22
1
2021
pubmed:
23
1
2021
medline:
23
1
2021
Statut:
epublish
Résumé
Gastric cancer (GC) is one of the most common cancers with high malignancy. In spite of the great development in diagnostic tools and application of anti-tumor drugs, we have not witnessed a significant increase in the survival time of patients with GC. Multiple studies have revealed that Wnt, Nrf2, MAPK, and PI3K/Akt signaling pathways are involved in GC invasion. Besides, long non-coding RNAs and microRNAs function as upstream mediators in GC malignancy. GC cells have acquired resistance to currently applied anti-tumor drugs. Besides, combination therapy is associated with higher anti-tumor activity. Resveratrol (Res) is a non-flavonoid polyphenol with high anti-tumor activity used in treatment of various cancers. A number of studies have demonstrated the potential of Res in regulation of molecular pathways involved in cancer malignancy. At the present review, we show that Res targets a variety of signaling pathways to induce apoptotic cell death and simultaneously, to inhibit the migration and metastasis of GC cells.
Identifiants
pubmed: 33478512
doi: 10.1186/s12935-021-01773-7
pii: 10.1186/s12935-021-01773-7
pmc: PMC7818776
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
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