Impaired Activated/Memory Regulatory T Cell Clonal Expansion Instigates Diabetes in NOD Mice.

Animals Diabetes Mellitus, Type 1 / metabolism Female Interleukin-2 / metabolism Male Mice Mice, Inbred C57BL Mice, Inbred NOD Receptors, Antigen, T-Cell / metabolism T-Lymphocytes, Regulatory / metabolism

Journal

Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763

Informations de publication

Date de publication:
04 2021
Historique:
received: 03 09 2020
accepted: 19 01 2021
pubmed: 23 1 2021
medline: 24 8 2021
entrez: 22 1 2021
Statut: ppublish

Résumé

Regulatory T cell (Treg) insufficiency licenses the destruction of insulin-producing pancreatic β-cells by autoreactive effector T cells (Teffs), causing spontaneous autoimmune diabetes in NOD mice. We investigated the contribution to diabetes of the T-cell receptor (TCR) repertoires of naive regulatory T cells (nTregs), activated/memory Tregs (amTregs), and CD4

Identifiants

DOI: 10.2337/db20-0896 PMID: 33479057
pubmed: 33479057
pii: db20-0896
doi: 10.2337/db20-0896
doi:

Substances chimiques

Interleukin-2 0
Receptors, Antigen, T-Cell 0

Banques de données

figshare
['10.2337/figshare.13611020']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

976-985

Informations de copyright

© 2021 by the American Diabetes Association.

Auteurs

Vanessa Mhanna (V)

Sorbonne Universite, INSERM, UMRS959 Immunology-Immunopathology-Immunotherapy Laboratory, Paris, France.

Gwladys Fourcade (G)

Sorbonne Universite, INSERM, UMRS959 Immunology-Immunopathology-Immunotherapy Laboratory, Paris, France.

Pierre Barennes (P)

Sorbonne Universite, INSERM, UMRS959 Immunology-Immunopathology-Immunotherapy Laboratory, Paris, France.

Valentin Quiniou (V)

Sorbonne Universite, INSERM, UMRS959 Immunology-Immunopathology-Immunotherapy Laboratory, Paris, France.
Clinical Investigation Center in Biotherapy and Inflammation-Immunopathology-Biotherapy Department, Assistance Publique-Hôpitaux de Paris, Hôpital Universitaire Pitié-Salpêtrière, Paris, France.

Hang P Pham (HP)

Statistics Department, ILTOO Pharma, Paris, France.

Paul-Gydeon Ritvo (PG)

Sorbonne Universite, INSERM, UMRS959 Immunology-Immunopathology-Immunotherapy Laboratory, Paris, France.

Faustine Brimaud (F)

Sorbonne Universite, INSERM, UMRS959 Immunology-Immunopathology-Immunotherapy Laboratory, Paris, France.

Bruno Gouritin (B)

Sorbonne Universite, INSERM, UMRS959 Immunology-Immunopathology-Immunotherapy Laboratory, Paris, France.

Guillaume Churlaud (G)

Sorbonne Universite, INSERM, UMRS959 Immunology-Immunopathology-Immunotherapy Laboratory, Paris, France.
Clinical Investigation Center in Biotherapy and Inflammation-Immunopathology-Biotherapy Department, Assistance Publique-Hôpitaux de Paris, Hôpital Universitaire Pitié-Salpêtrière, Paris, France.

Adrien Six (A)

Sorbonne Universite, INSERM, UMRS959 Immunology-Immunopathology-Immunotherapy Laboratory, Paris, France.

Encarnita Mariotti-Ferrandiz (E)

Sorbonne Universite, INSERM, UMRS959 Immunology-Immunopathology-Immunotherapy Laboratory, Paris, France.

David Klatzmann (D)

Sorbonne Universite, INSERM, UMRS959 Immunology-Immunopathology-Immunotherapy Laboratory, Paris, France david.klatzmann@sorbonne-universite.fr.
Clinical Investigation Center in Biotherapy and Inflammation-Immunopathology-Biotherapy Department, Assistance Publique-Hôpitaux de Paris, Hôpital Universitaire Pitié-Salpêtrière, Paris, France.
ORCID: 0000-0002-0054-3422

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Impaired Activated/Memory Regulatory T Cell...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Diabète de type 1 › Impaired Activated/Memory Regulatory T Cell...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Interleukine-2 › Impaired Activated/Memory Regulatory T Cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Impaired Activated/Memory Regulatory T Cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Impaired Activated/Memory Regulatory T Cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée NOD › Impaired Activated/Memory Regulatory T Cell...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › Impaired Activated/Memory Regulatory T Cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Impaired Activated/Memory Regulatory T Cell...