Developmental cell programs are co-opted in inflammatory skin disease.
Animals
Atlases as Topic
Cell Movement
Datasets as Topic
Dendritic Cells
/ immunology
Dermatitis, Atopic
/ embryology
Dermatologic Agents
/ pharmacology
Humans
Immunity, Innate
/ genetics
Methotrexate
/ pharmacology
Mice
Phagocytes
/ immunology
Psoriasis
/ embryology
Single-Cell Analysis
Skin
/ cytology
T-Lymphocytes
/ immunology
Transcriptome
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
22 01 2021
22 01 2021
Historique:
received:
21
12
2019
revised:
03
09
2020
accepted:
01
12
2020
entrez:
22
1
2021
pubmed:
23
1
2021
medline:
26
2
2021
Statut:
ppublish
Résumé
The skin confers biophysical and immunological protection through a complex cellular network established early in embryonic development. We profiled the transcriptomes of more than 500,000 single cells from developing human fetal skin, healthy adult skin, and adult skin with atopic dermatitis and psoriasis. We leveraged these datasets to compare cell states across development, homeostasis, and disease. Our analysis revealed an enrichment of innate immune cells in skin during the first trimester and clonal expansion of disease-associated lymphocytes in atopic dermatitis and psoriasis. We uncovered and validated in situ a reemergence of prenatal vascular endothelial cell and macrophage cellular programs in atopic dermatitis and psoriasis lesional skin. These data illustrate the dynamism of cutaneous immunity and provide opportunities for targeting pathological developmental programs in inflammatory skin diseases.
Identifiants
pubmed: 33479125
pii: 371/6527/eaba6500
doi: 10.1126/science.aba6500
pmc: PMC7611557
mid: EMS132468
pii:
doi:
Substances chimiques
Dermatologic Agents
0
Methotrexate
YL5FZ2Y5U1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MC_UU_12022/3
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U137881017
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 221052
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00008/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : G116/150
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R006237/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 088555
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12010/5
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021, American Association for the Advancement of Science.
Références
Immunity. 2015 Jul 21;43(1):146-60
pubmed: 26187413
Science. 2015 Jan 23;347(6220):1260419
pubmed: 25613900
Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):e47-55
pubmed: 23162017
Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):E2940-E2949
pubmed: 29531070
PLoS One. 2014 Mar 18;9(3):e92187
pubmed: 24642963
J Clin Invest. 2009 Jul;119(7):1794-805
pubmed: 19587454
Sci Adv. 2019 Dec 11;5(12):eaax8898
pubmed: 31844668
Curr Opin Virol. 2011 Dec;1(6):519-25
pubmed: 22328912
Nature. 2019 Oct;574(7778):365-371
pubmed: 31597962
J Exp Med. 2006 Jan 23;203(1):27-33
pubmed: 16390938
J Leukoc Biol. 2017 Jun;101(6):1393-1403
pubmed: 28270408
BMC Biol. 2017 May 19;15(1):45
pubmed: 28526034
J Immunol. 2015 Nov 15;195(10):4953-61
pubmed: 26466959
Cell Rep. 2017 Sep 19;20(12):2921-2934
pubmed: 28930685
J Immunol. 2008 Jul 1;181(1):186-9
pubmed: 18566383
Nucleic Acids Res. 2012 Jan;40(Database issue):D940-6
pubmed: 22080554
Eur J Immunol. 2015 Aug;45(8):2171-82
pubmed: 26031799
J Exp Med. 2009 Dec 21;206(13):3089-100
pubmed: 19995948
Genes Immun. 2013 Jan;14(1):1-6
pubmed: 23190643
Cell Rep. 2019 Mar 12;26(11):3116-3131.e5
pubmed: 30865898
Nat Rev Immunol. 2007 Dec;7(12):923-7
pubmed: 17965637
Immunity. 2017 Aug 15;47(2):349-362.e5
pubmed: 28801233
Commun Biol. 2020 Apr 23;3(1):188
pubmed: 32327715
Nat Genet. 2019 Dec;51(12):1702-1713
pubmed: 31768071
J Exp Med. 2009 Feb 16;206(2):371-85
pubmed: 19171766
Sci Transl Med. 2015 Jan 7;7(269):269rv1
pubmed: 25568072
Cell Rep. 2018 Oct 23;25(4):871-883
pubmed: 30355494
J Invest Dermatol. 2012 Aug;132(8):1951-3
pubmed: 22797297
Cancer Cell. 2020 Mar 16;37(3):421
pubmed: 32183954
Science. 2017 Apr 21;356(6335):
pubmed: 28428369
Genome Biol. 2018 Feb 6;19(1):15
pubmed: 29409532
Bioinformatics. 2020 Sep 15;36(18):4817-4818
pubmed: 32614448
Nature. 2016 Nov 10;539(7628):309-313
pubmed: 27806376
J Invest Dermatol. 2009 Sep;129(9):2175-83
pubmed: 19295614
J Allergy Clin Immunol. 2020 Nov;146(5):1056-1069
pubmed: 32344053
Cell Syst. 2016 Sep 28;3(3):221-237.e9
pubmed: 27641957
J Dermatol Sci. 2020 Jan;97(1):41-49
pubmed: 31836271
Front Immunol. 2015 Jun 02;6:260
pubmed: 26082777
Cell. 2010 Feb 19;140(4):460-76
pubmed: 20178740
J Dtsch Dermatol Ges. 2020 Jan;18(1):17-25
pubmed: 31642606
J Invest Dermatol. 2014 Apr;134(4):965-974
pubmed: 24352044
J Invest Dermatol. 2018 Apr;138(4):802-810
pubmed: 29080679
Development. 2015 Sep 15;142(18):3073-6
pubmed: 26395135
Immunity. 2009 Aug 21;31(2):178-80
pubmed: 19699168
Elife. 2017 Oct 18;6:
pubmed: 29043977
J Invest Dermatol. 2018 Apr;138(4):811-825
pubmed: 29391249
J Exp Med. 2018 Mar 5;215(3):773-783
pubmed: 29440362
Obstet Gynecol. 1984 Jan;63(1):26-32
pubmed: 6691014
Nat Genet. 2020 Aug;52(8):790-799
pubmed: 32690948
Science. 2020 Feb 21;367(6480):
pubmed: 32079746
Nat Immunol. 2015 Mar;16(3):306-17
pubmed: 25621825
J Exp Med. 2012 Jun 4;209(6):1167-81
pubmed: 22565823
Cell Syst. 2019 Apr 24;8(4):281-291.e9
pubmed: 30954476
Immunity. 2016 Aug 16;45(2):305-18
pubmed: 27533013
J Exp Med. 2014 Jan 13;211(1):89-104
pubmed: 24395888
Nat Commun. 2018 Jul 2;9(1):2570
pubmed: 29967419
Nat Commun. 2019 Jun 21;10(1):2759
pubmed: 31227717
Nat Methods. 2017 Sep 29;14(10):935-936
pubmed: 28960196
J Invest Dermatol. 2019 Jul;139(7):1480-1489
pubmed: 30641038
Nat Biotechnol. 2014 Apr;32(4):381-386
pubmed: 24658644
Cell Rep. 2016 Jul 12;16(2):392-404
pubmed: 27346359
Immunity. 2012 Jul 27;37(1):60-73
pubmed: 22795876
Immunity. 2014 Sep 18;41(3):465-477
pubmed: 25200712
Sci Rep. 2019 Mar 26;9(1):5233
pubmed: 30914743
Immunity. 2013 Dec 12;39(6):1171-81
pubmed: 24332034
Cell. 2019 Jun 13;177(7):1888-1902.e21
pubmed: 31178118
FASEB J. 2020 Mar;34(3):3677-3692
pubmed: 31930613
Nature. 2020 Apr;580(7802):257-262
pubmed: 32269339
J Invest Dermatol. 2015 Jan;135(1):160-169
pubmed: 25111616
Nucleic Acids Res. 2018 Jan 4;46(D1):D836-D842
pubmed: 29092072
Bioinformatics. 2020 Feb 1;36(3):964-965
pubmed: 31400197
Cancer Cell. 2006 Mar;9(3):157-73
pubmed: 16530701
J Immunol. 2005 Jun 15;174(12):7875-82
pubmed: 15944293
Nat Immunol. 2016 Jun 21;17(7):758-64
pubmed: 27328005
J Allergy Clin Immunol. 2020 Jun;145(6):1615-1628
pubmed: 32035984
J Invest Dermatol. 1999 Jun;112(6):882-6
pubmed: 10383733
Immunity. 2018 Feb 20;48(2):202-213
pubmed: 29466753
Nature. 2013 Apr 25;496(7446):445-55
pubmed: 23619691
Cell Syst. 2021 Jul 21;12(7):706-715.e4
pubmed: 34293324
Eur J Immunol. 2012 Feb;42(2):476-88
pubmed: 22101742
PLoS One. 2016 Jan 29;11(1):e0148351
pubmed: 26824609
Immunity. 2013 Nov 14;39(5):925-38
pubmed: 24184057
Blood. 2001 Aug 1;98(3):743-53
pubmed: 11468175
Cell. 2018 Feb 8;172(4):650-665
pubmed: 29425488
Science. 2020 Aug 14;369(6505):787-793
pubmed: 32675289
Curr Opin Immunol. 2017 Oct;48:68-73
pubmed: 28869867