Role of osteogenic Dickkopf-1 in bone remodeling and bone healing in mice with type I diabetes mellitus.
Adaptor Proteins, Signal Transducing
/ blood
Animals
Blood Glucose
Bone Diseases, Metabolic
/ genetics
Bone Remodeling
/ genetics
Bone and Bones
/ metabolism
Diabetes Mellitus, Experimental
/ genetics
Diabetes Mellitus, Type 1
/ genetics
Disease Models, Animal
Humans
Intercellular Signaling Peptides and Proteins
/ genetics
Mice
Mice, Knockout
Osteoblasts
/ metabolism
Osteoclasts
/ metabolism
Osteocytes
/ metabolism
Osteogenesis
/ genetics
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 01 2021
21 01 2021
Historique:
received:
16
08
2020
accepted:
05
01
2021
entrez:
22
1
2021
pubmed:
23
1
2021
medline:
24
9
2021
Statut:
epublish
Résumé
Type 1 diabetes mellitus (T1DM) is associated with low bone mass and a higher risk for fractures. Dickkopf-1 (Dkk1), which inhibits Wnt signaling, osteoblast function, and bone formation, has been found to be increased in the serum of patients with T1DM. Here, we investigated the functional role of Dkk1 in T1DM-induced bone loss in mice. T1DM was induced in 10-week-old male mice with Dkk1-deficiency in late osteoblasts/osteocytes (Dkk1
Identifiants
pubmed: 33479403
doi: 10.1038/s41598-021-81543-7
pii: 10.1038/s41598-021-81543-7
pmc: PMC7820472
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Blood Glucose
0
Dkk1 protein, mouse
0
Intercellular Signaling Peptides and Proteins
0
Sost protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1920Références
Endocrinology. 2003 Jan;144(1):346-52
pubmed: 12488363
JBMR Plus. 2020 Apr 28;4(6):e10364
pubmed: 32537550
J Clin Invest. 1999 Nov;104(10):1363-74
pubmed: 10562298
Diabetes. 2003 Jun;52(6):1502-10
pubmed: 12765963
Curr Osteoporos Rep. 2016 Dec;14(6):310-319
pubmed: 27704393
J Clin Endocrinol Metab. 2018 May 1;103(5):1921-1928
pubmed: 29506222
J Clin Endocrinol Metab. 2017 Aug 1;102(8):2887-2895
pubmed: 28531321
Eur J Trauma Emerg Surg. 2018 Aug;44(4):573-580
pubmed: 28795198
Diabetes. 2005 Oct;54(10):2875-81
pubmed: 16186388
J Bone Miner Res. 2018 Sep;33(9):1698-1707
pubmed: 29734465
J Bone Miner Res. 2005 Sep;20(9):1647-58
pubmed: 16059636
Nat Med. 2007 Feb;13(2):156-63
pubmed: 17237793
Osteoporos Int. 2017 Mar;28(3):945-953
pubmed: 27766367
Osteoporos Int. 2016 Apr;27(4):1631-1643
pubmed: 26588909
Am J Epidemiol. 2007 Sep 1;166(5):495-505
pubmed: 17575306
JAMA. 2007 Jun 27;297(24):2716-24
pubmed: 17595272
Int J Biochem Cell Biol. 2004 May;36(5):840-8
pubmed: 15006636
Connect Tissue Res. 2016 Jul;57(4):277-89
pubmed: 27028715
J Cell Physiol. 2015 Aug;230(8):1944-53
pubmed: 25641511
Front Pharmacol. 2019 Jan 08;9:1517
pubmed: 30670968
Sci Rep. 2016 Jul 29;6:30639
pubmed: 27468810
Lancet. 2000 Mar 11;355(9207):873-6
pubmed: 10752702
J Clin Endocrinol Metab. 2017 Apr 1;102(4):1174-1181
pubmed: 28388723
Lancet. 2014 Jan 4;383(9911):69-82
pubmed: 23890997
Endocrinology. 2007 Jan;148(1):198-205
pubmed: 17053023
PLoS One. 2012;7(10):e47600
pubmed: 23094067
Blood. 2007 Mar 1;109(5):2106-11
pubmed: 17068150
Bone. 2001 Feb;28(2):195-201
pubmed: 11182378
Endocrinology. 2008 Apr;149(4):1697-704
pubmed: 18162513
Diabetologia. 2010 Mar;53(3):536-40
pubmed: 19943155
Biomed Pharmacother. 2019 Jul;115:108570
pubmed: 31054509
J Cell Physiol. 2011 Feb;226(2):477-83
pubmed: 20677222
J Endocrinol Invest. 2000 May;23(5):295-303
pubmed: 10882147
Nat Commun. 2016 May 27;7:11505
pubmed: 27230681
Curr Protoc Pharmacol. 2015 Sep 01;70:5.47.1-5.47.20
pubmed: 26331889
J Cell Physiol. 2013 Feb;228(2):349-61
pubmed: 22718269
Calcif Tissue Int. 2018 Jan;102(1):105-116
pubmed: 29105022
Int J Mol Sci. 2020 Jul 26;21(15):
pubmed: 32722636
FEBS Lett. 2010 Jul 16;584(14):3095-100
pubmed: 20621835
J Clin Invest. 2006 May;116(5):1202-9
pubmed: 16670761
Pediatr Diabetes. 2020 May;21(3):505-514
pubmed: 31970841
J Bone Miner Res. 2006 Jun;21(6):934-45
pubmed: 16753024
J Cell Biochem. 2007 Dec 15;102(6):1343-57
pubmed: 17975793
J Bone Miner Res. 2007 Sep;22(9):1317-28
pubmed: 17501667
Bone Rep. 2017 Jul 04;7:1-8
pubmed: 28736738
Bone. 2007 Feb;40(2):485-92
pubmed: 17055793
J Orthop Res. 2011 Mar;29(3):414-8
pubmed: 20939046
Int J Mol Med. 2011 Sep;28(3):455-62
pubmed: 21567076
Int J Oral Maxillofac Surg. 2001 Feb;30(1):70-4
pubmed: 11289625
Bone. 2015 Feb;71:63-75
pubmed: 25263522
J Bone Miner Res. 2010 Jul;25(7):1468-86
pubmed: 20533309
Exp Mol Med. 2018 Dec 5;50(12):1-14
pubmed: 30518745
Front Immunol. 2019 Dec 10;10:2924
pubmed: 31921182
Bone. 2016 Jan;82:101-7
pubmed: 26211996
J Cell Physiol. 2012 Nov;227(11):3539-45
pubmed: 22378151
Biol Proced Online. 2009 Mar 06;11:296-315
pubmed: 19495918
Pediatr Diabetes. 2019 Aug;20(5):510-522
pubmed: 30941847
J Clin Endocrinol Metab. 1995 Apr;80(4):1194-202
pubmed: 7714089
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
J Bone Miner Res. 2015 Aug;30(8):1386-93
pubmed: 25627460