Prognostic neuroimaging biomarkers of trauma-related psychopathology: resting-state fMRI shortly after trauma predicts future PTSD and depression symptoms in the AURORA study.

Brain / diagnostic imaging Depression / diagnostic imaging Humans Magnetic Resonance Imaging Neuroimaging Prognosis Stress Disorders, Post-Traumatic / diagnostic imaging

Journal

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
ISSN: 1740-634X
Titre abrégé: Neuropsychopharmacology
Pays: England
ID NLM: 8904907

Informations de publication

Date de publication:
06 2021
Historique:
received: 03 11 2020
accepted: 16 12 2020
revised: 12 12 2020
pubmed: 23 1 2021
medline: 24 6 2021
entrez: 22 1 2021
Statut: ppublish

Résumé

Neurobiological markers of future susceptibility to posttraumatic stress disorder (PTSD) may facilitate identification of vulnerable individuals in the early aftermath of trauma. Variability in resting-state networks (RSNs), patterns of intrinsic functional connectivity across the brain, has previously been linked to PTSD, and may thus be informative of PTSD susceptibility. The present data are part of an initial analysis from the AURORA study, a longitudinal, multisite study of adverse neuropsychiatric sequalae. Magnetic resonance imaging (MRI) data from 109 recently (i.e., ~2 weeks) traumatized individuals were collected and PTSD and depression symptoms were assessed at 3 months post trauma. We assessed commonly reported RSNs including the default mode network (DMN), central executive network (CEN), and salience network (SN). We also identified a proposed arousal network (AN) composed of a priori brain regions important for PTSD: the amygdala, hippocampus, mamillary bodies, midbrain, and pons. Primary analyses assessed whether variability in functional connectivity at the 2-week imaging timepoint predicted 3-month PTSD symptom severity. Left dorsolateral prefrontal cortex (DLPFC) to AN connectivity at 2 weeks post trauma was negatively related to 3-month PTSD symptoms. Further, right inferior temporal gyrus (ITG) to DMN connectivity was positively related to 3-month PTSD symptoms. Both DLPFC-AN and ITG-DMN connectivity also predicted depression symptoms at 3 months. Our results suggest that, following trauma exposure, acutely assessed variability in RSN connectivity was associated with PTSD symptom severity approximately two and a half months later. However, these patterns may reflect general susceptibility to posttraumatic dysfunction as the imaging patterns were not linked to specific disorder symptoms, at least in the subacute/early chronic phase. The present data suggest that assessment of RSNs in the early aftermath of trauma may be informative of susceptibility to posttraumatic dysfunction, with future work needed to understand neural markers of long-term (e.g., 12 months post trauma) dysfunction. Furthermore, these findings are consistent with neural models suggesting that decreased top-down cortico-limbic regulation and increased network-mediated fear generalization may contribute to ongoing dysfunction in the aftermath of trauma.

Identifiants

DOI: 10.1038/s41386-020-00946-8 PMID: 33479509 PMC: PMC8134491
pubmed: 33479509
doi: 10.1038/s41386-020-00946-8
pii: 10.1038/s41386-020-00946-8
pmc: PMC8134491
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

1263-1271

Subventions

Organisme : NIMH NIH HHS
ID : K01 MH121653
Pays : United States
Organisme : NIMH NIH HHS
ID : K00 MH119603
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH118771
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH117009
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH110925
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH118467
Pays : United States

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Auteurs

Nathaniel G Harnett (NG)

Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA. nharnett@mclean.harvard.edu.
Department of Psychiatry, Harvard Medical School, Boston, MA, USA. nharnett@mclean.harvard.edu.
ORCID: 0000-0001-5346-2012

Sanne J H van Rooij (SJH)

Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.
ORCID: 0000-0002-0160-7248

Timothy D Ely (TD)

Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.

Lauren A M Lebois (LAM)

Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA.
Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0001-5816-9181

Vishnu P Murty (VP)

Department of Psychology, Temple University, Philadelphia, PA, USA.

Tanja Jovanovic (T)

Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA.
ORCID: 0000-0002-6456-0053

Sarah B Hill (SB)

Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA.

Nathalie M Dumornay (NM)

Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA.

Julia B Merker (JB)

Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA.

Steve E Bruce (SE)

Department of Psychological Sciences, University of Missouri - St. Louis, Springfield, MO, USA.

Stacey L House (SL)

Department of Emergency Medicine, Washington University School of Medicine, St. Louis, MO, USA.

Francesca L Beaudoin (FL)

Department of Emergency Medicine & Health Services, Policy, and Practice, Rhode Island Hospital and The Miriam Hospital, The Alpert Medical School of Brown University, Providence, RI, USA.

Xinming An (X)

Institute of Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Donglin Zeng (D)

Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Thomas C Neylan (TC)

Departments of Psychiatry and Neurology, University of California at San Francisco, San Francisco, CA, USA.

Gari D Clifford (GD)

Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA.
Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.

Sarah D Linnstaedt (SD)

Institute of Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
ORCID: 0000-0001-5295-7072

Laura T Germine (LT)

Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA.

Kenneth A Bollen (KA)

Department of Psychology and Neuroscience, Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Scott L Rauch (SL)

Department of Psychiatry, McLean Hospital, Belmont, MA, USA.

Christopher Lewandowski (C)

Department of Emergency Medicine, Henry Ford Health System, Detroit, MI, USA.
ORCID: 0000-0001-8297-0024

Phyllis L Hendry (PL)

Department of Emergency Medicine, University of Florida College of Medicine, Jacksonville, FL, USA.

Sophia Sheikh (S)

Department of Emergency Medicine, University of Florida College of Medicine, Jacksonville, FL, USA.
ORCID: 0000-0003-1939-3126

Alan B Storrow (AB)

Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Paul I Musey (PI)

Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

John P Haran (JP)

Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA, USA.

Christopher W Jones (CW)

Department of Emergency Medicine, Cooper Medical School of Rowan University, Camden, NJ, USA.

Brittany E Punches (BE)

Department of Emergency Medicine, College of Medicine & College of Nursing, University of Cincinnati, Cincinnati, OH, USA.
ORCID: 0000-0002-7546-1966

Robert A Swor (RA)

Department of Emergency Medicine, Oakland University William Beaumont School of Medicine, Rochester, MI, USA.

Meghan E McGrath (ME)

Department of Emergency Medicine, Boston Medical Center, Boston, MA, USA.

Jose L Pascual (JL)

Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Mark J Seamon (MJ)

Division of Traumatology, Surgical Critical Care and Emergency Surgery, University of Pennsylvania, Philadelphia, PA, USA.

Kamran Mohiuddin (K)

Department of Emergency Medicine, Einstein Medical Center, Philadelphia, PA, USA.

Anna M Chang (AM)

Department of Emergency Medicine, Jefferson University Hospitals, Philadelphia, PA, USA.

Claire Pearson (C)

Department of Emergency Medicine, Wayne State University, Detroit, MI, USA.

David A Peak (DA)

Department of Emergency Medicine, Massachusetts General Hospital, Massachusetts, MA, USA.

Robert M Domeier (RM)

Department of Emergency Medicine, Saint Joseph Mercy Hospital, Ann Arbor, MI, USA.

Niels K Rathlev (NK)

Department of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield, MO, USA.

Leon D Sanchez (LD)

Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA.

Robert H Pietrzak (RH)

Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, VA Connecticut Healthcare System, West Haven, CT, USA.

Jutta Joormann (J)

Department of Psychology, Yale University, New Haven, CT, USA.

Deanna M Barch (DM)

Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA.
ORCID: 0000-0003-1693-8506

Diego A Pizzagalli (DA)

Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA.
Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-7772-1143

John F Sheridan (JF)

Department of Biosciences and Neuroscience, OSU Wexner Medical Center, Columbus, OH, USA.
Institute for Behavioral Medicine Research, OSU Wexner Medical Center, Columbus, OH, USA.
ORCID: 0000-0002-6927-0266

Steven E Harte (SE)

Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Department of Internal Medicine-Rheumatology, University of Michigan Medical School, Ann Arbor, MI, USA.

James M Elliott (JM)

The Kolling Institute of Medical Research, Northern Clinical School, University of Sydney, Camperdown, NSW, Australia.
Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia.
Physical Therapy & Human Movement Sciences, Feinberg School of Medicine at Northwestern University, Chicago, IL, USA.

Ronald C Kessler (RC)

Department of Health Care Policy, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0003-4831-2305

Karestan C Koenen (KC)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Samuel Mclean (S)

Institute of Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
ORCID: 0000-0001-9482-3582

Kerry J Ressler (KJ)

Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA.
Department of Psychiatry, Harvard Medical School, Boston, MA, USA.

Jennifer S Stevens (JS)

Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA. jennifer.stevens@emory.edu.
ORCID: 0000-0003-4674-0314

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Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prognostic neuroimaging biomarkers of...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Dépression › Prognostic neuroimaging biomarkers of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Prognostic neuroimaging biomarkers of...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Prognostic neuroimaging biomarkers of...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Prognostic neuroimaging biomarkers of...
questionsmedicales.fr › Diagnostic › Pronostic › Prognostic neuroimaging biomarkers of...
questionsmedicales.fr › Troubles mentaux › Troubles liés aux traumatismes et au stress › Troubles de stress traumatique › Troubles de stress post-traumatique › Prognostic neuroimaging biomarkers of...