Synthesis, evaluation and molecular modelling of piceatannol analogues as arginase inhibitors.
Journal
RSC medicinal chemistry
ISSN: 2632-8682
Titre abrégé: RSC Med Chem
Pays: England
ID NLM: 101759460
Informations de publication
Date de publication:
01 May 2020
01 May 2020
Historique:
received:
08
01
2020
accepted:
29
03
2020
entrez:
22
1
2021
pubmed:
23
1
2021
medline:
23
1
2021
Statut:
epublish
Résumé
Arginase is involved in a wide range of pathologies including cardiovascular diseases and infectious diseases whilst it is also a promising target to improve cancer immunotherapy. To date, only a limited number of inhibitors of arginase have been reported. Natural polyphenols, among them piceatannol, are moderate inhibitors of arginase. Herein, we report our efforts to investigate catechol binding by quantum chemistry and generate analogues of piceatannol. In this work, we synthesized a novel series of amino-polyphenols which were then evaluated as arginase inhibitors. Their structure-activity relationships were elucidated by deep quantum chemistry modelling. 4-((3,4-Dihydroxybenzyl)amino)benzene-1,2-diol
Identifiants
pubmed: 33479657
doi: 10.1039/d0md00011f
pii: d0md00011f
pmc: PMC7593889
doi:
Types de publication
Journal Article
Langues
eng
Pagination
559-568Informations de copyright
This journal is © The Royal Society of Chemistry 2020.
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